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Epinephrine inhalation
Epinephrine inhalation is a bronchodilator that stimulates alpha and beta-adrenergic receptors to rapidly relieve acute bronchospasm and airway obstruction.
Epinephrine inhalation is a bronchodilator that stimulates alpha and beta-adrenergic receptors to rapidly relieve acute bronchospasm and airway obstruction. Used for Acute bronchospasm and croup in pediatric patients, Emergency relief of acute airway obstruction.
At a glance
| Generic name | Epinephrine inhalation |
|---|---|
| Also known as | oxymetazoline lidocaine |
| Sponsor | Amphastar Pharmaceuticals, Inc. |
| Drug class | Adrenergic agonist bronchodilator |
| Target | Alpha-1, beta-1, and beta-2 adrenergic receptors |
| Modality | Small molecule |
| Therapeutic area | Pulmonology / Respiratory |
| Phase | FDA-approved |
Mechanism of action
Epinephrine acts as a non-selective adrenergic agonist, binding to alpha-1, beta-1, and beta-2 adrenergic receptors. When inhaled, it rapidly reaches the airways where beta-2 receptor stimulation causes bronchial smooth muscle relaxation and bronchodilation, while alpha-1 stimulation reduces mucosal edema. This dual action provides rapid symptomatic relief of acute airway obstruction.
Approved indications
- Acute bronchospasm and croup in pediatric patients
- Emergency relief of acute airway obstruction
Common side effects
- Tremor
- Tachycardia
- Nervousness or anxiety
- Headache
- Palpitations
Key clinical trials
- Feasibility of Breathwork Intervention With Older Adults After Knee Surgery (NA)
- Platform of Randomized Adaptive Clinical Trials in Critical Illness (NA)
- Effects of Inhaled Epinephrine on Systemic Allergic Reactions During Allergy Testing, Immunotherapy or Oral Challenges (PHASE1)
- Randomized Controlled Trial Comparing Standard Versus Positive Pressure Nebulization in Infants With Bronchiolitis to Reduce Hospital Admissions (NA)
- A Pilot Study of Local Anesthesia for Inguinal Hernia Surgery in Older Adults (NA)
- The Impact of Intraperitoneal Spray Combined With Intravenous Lidocaine on Postoperative Pain After Myomectomy (NA)
- Long-term Effect of Steroid on Metabolic Diseases in Asthmatics
- Therapeutic Relevance of Abnormal Airway Morphology in Asthma (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |