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Epidural PCA Ropivacaine
Ropivacaine is a local anesthetic that blocks sodium channels in nerve fibers, preventing the initiation and propagation of action potentials to produce regional anesthesia.
Ropivacaine is a local anesthetic that blocks sodium channels in nerve fibers, preventing the initiation and propagation of action potentials to produce regional anesthesia. Used for Epidural anesthesia and analgesia for surgical procedures, Postoperative pain management via patient-controlled epidural analgesia.
At a glance
| Generic name | Epidural PCA Ropivacaine |
|---|---|
| Also known as | Epidural patient-controlled analgesia Ropivacaine |
| Sponsor | Keimyung University Dongsan Medical Center |
| Drug class | Local anesthetic (amide) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia/Pain Management |
| Phase | Phase 3 |
Mechanism of action
Ropivacaine is an amide-type local anesthetic that reversibly inhibits sodium influx through voltage-gated sodium channels in nerve cell membranes. When administered via epidural patient-controlled analgesia (PCA), it provides segmental anesthesia and analgesia by blocking sensory and motor nerve conduction in the epidural space. This allows patients to self-administer doses for pain management during and after surgical procedures.
Approved indications
- Epidural anesthesia and analgesia for surgical procedures
- Postoperative pain management via patient-controlled epidural analgesia
Common side effects
- Hypotension
- Bradycardia
- Headache
- Nausea
- Urinary retention
- Pruritus
- Systemic toxicity (at high doses)
Key clinical trials
- Continuous Wound Catheter Analgesia Associated With Intravenous Morphine PCA After Thoracotomy (PHASE4)
- Paravertebral Analgesia Associated With Intravenous Morphine PCA After Thoracotomy (PHASE3)
- Epidural Association of Morphine and Ropivacaine for Cancer Pain Treatment (NA)
- The Effect of Intravenous Infusion of Tramadol-ondansetron on Recovery After Caesarean Section.
- Enhanced Recovery After Urologic Surgery (NA)
- Multimodal Analgesia Versus Peripheral Nerve Block for Postoperative Pain Management After Lower Limb Injury Surgery (NA)
- Study on the Effects of Multimodal Analgesia Regimens on Postoperative Analgesia and Gastrointestinal Function Recovery After Laparoscopic Abdominal Surgery (NA)
- Rhomboid Intercostal Block with Subserratus Plane Block in Bariatric Surgery (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Epidural PCA Ropivacaine CI brief — competitive landscape report
- Epidural PCA Ropivacaine updates RSS · CI watch RSS
- Keimyung University Dongsan Medical Center portfolio CI