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ephedrine and phenylephrine
ephedrine and phenylephrine is a Sympathomimetic amine / Adrenergic agonist Small molecule drug developed by University Hospital, Clermont-Ferrand. It is currently FDA-approved for Hypotension (acute management), Nasal congestion and upper airway obstruction, Anaphylaxis (adjunctive).
Ephedrine and phenylephrine are sympathomimetic agents that stimulate alpha and beta adrenergic receptors to increase blood pressure and improve nasal/airway congestion.
Ephedrine and phenylephrine are sympathomimetic agents that stimulate alpha and beta adrenergic receptors to increase blood pressure and improve nasal/airway congestion. Used for Hypotension (acute management), Nasal congestion and upper airway obstruction, Anaphylaxis (adjunctive).
At a glance
| Generic name | ephedrine and phenylephrine |
|---|---|
| Sponsor | University Hospital, Clermont-Ferrand |
| Drug class | Sympathomimetic amine / Adrenergic agonist |
| Target | Alpha-1 adrenergic receptor, beta-1 adrenergic receptor, beta-2 adrenergic receptor |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular / Respiratory |
| Phase | FDA-approved |
Mechanism of action
Ephedrine acts as a mixed alpha and beta-adrenergic agonist, increasing heart rate, cardiac output, and peripheral vasoconstriction to elevate blood pressure. Phenylephrine is a selective alpha-1 adrenergic agonist that causes vasoconstriction and increases systemic vascular resistance. Together, this combination provides both direct sympathomimetic effects and indirect norepinephrine release, making it useful for hypotension and decongestant purposes.
Approved indications
- Hypotension (acute management)
- Nasal congestion and upper airway obstruction
- Anaphylaxis (adjunctive)
Common side effects
- Tachycardia
- Tremor
- Anxiety
- Insomnia
- Headache
- Hypertension
- Palpitations
Key clinical trials
- Nasal Decongestant to Reduce Perioperative Adverse Events in Children With Upper Respiratory Track Infections Having Anesthesia. (PHASE4)
- Ephedrine Versus Phenylephrine for Spinal Block - Related Hypotension in Cesarean Delivery
- Intraoperative Goal-directed Blood Pressure and Dexmedetomidine on Outcomes (PHASE4)
- Effect of Ephedrine, Phenylepinephrine, and Norepinephrine on Myometrial Contractility in Pregnant People With Type II and Gestational Diabetes During Cesarean Section: An In-vitro Study (NA)
- Effects of Vasopressors on Cerebral Hemodynamics in Patients With Carotid Endarterectomy (TCD Part) (NA)
- The Contractile Response of the Thoracic Aorta to Vasoactive Substances
- Influence of Nociception Level Monitor (NOL) Guided Analgesic Delivery on Robot-assisted Colorectal Surgery (NA)
- Fluid Therapy and Glycocalyx Shedding During Moderate Surgery (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- ephedrine and phenylephrine CI brief — competitive landscape report
- ephedrine and phenylephrine updates RSS · CI watch RSS
- University Hospital, Clermont-Ferrand portfolio CI
Frequently asked questions about ephedrine and phenylephrine
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Related
- Drug class: All Sympathomimetic amine / Adrenergic agonist drugs
- Target: All drugs targeting Alpha-1 adrenergic receptor, beta-1 adrenergic receptor, beta-2 adrenergic receptor
- Manufacturer: University Hospital, Clermont-Ferrand — full pipeline
- Therapeutic area: All drugs in Cardiovascular / Respiratory
- Indication: Drugs for Hypotension (acute management)
- Indication: Drugs for Nasal congestion and upper airway obstruction
- Indication: Drugs for Anaphylaxis (adjunctive)
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing