Last reviewed 2026-04-22 · How we verify

EndoSequence

EndoSequence is a bioresorbable endodontic sealer that sets through a hydration reaction to create a biocompatible root canal filling material.

EndoSequence is a bioresorbable endodontic sealer that sets through a hydration reaction to create a biocompatible root canal filling material. Used for Root canal obturation and sealing in endodontic therapy.

At a glance

Mechanism of action

EndoSequence is a calcium silicate-based root canal sealer designed for endodontic therapy. It sets via a hydration reaction rather than a setting reaction dependent on moisture, allowing it to harden in the presence of moisture. The material is bioresorbable and promotes periapical healing through its bioactive properties.

Approved indications

• Root canal obturation and sealing in endodontic therapy

Common side effects

No common side effects on file.

Key clinical trials

• Vital Pulp Therapy vs. Root Canal Treatment in Mature Teeth With Irreversible Pulpitis (NA)
• Influence of Sonic Activation of Root Sealers on Post-Operative Pain (NA)
• Assessing Success of MTA and Pre-mixed Bioceramic in Mature Teeth With Irreversible Pulpitis With Full Pulpotomy. (PHASE4)
• Comparison of Post-Operative Pain After Use of Calcium Hydroxide and Bio Ceramic Sealer for Root Canal Treatment. (EARLY_PHASE1)
• Discoloration of Endosequence and Mineral Trioxde Aggregate in Revascularization of Necrotic Immature Permanent Teeth (NA)
• Clinical Assessment of 3 Differant Obturation Sealers on Postoprative Pain and Swelling (PHASE2, PHASE3)
• Post-endodontic Pain Survey (NA)
• Single Visit Root Canal Treatment :Incidence of Postoperative Pain Using Two Different Sealers (NA)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.