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emollient cream
An emollient cream hydrates and softens the skin by forming an occlusive barrier that reduces transepidermal water loss.
An emollient cream hydrates and softens the skin by forming an occlusive barrier that reduces transepidermal water loss. Used for Dry skin and xerosis, Eczema and atopic dermatitis (supportive care), General skin irritation and chafing.
At a glance
| Generic name | emollient cream |
|---|---|
| Sponsor | Children's Hospital Medical Center, Cincinnati |
| Drug class | Topical emollient |
| Modality | Small molecule |
| Therapeutic area | Dermatology |
| Phase | FDA-approved |
Mechanism of action
Emollient creams work by penetrating the stratum corneum and trapping moisture within the skin, while also smoothing rough skin texture. They typically contain humectants (which draw water into the skin) and occlusives (which seal moisture in), providing symptomatic relief for dry, irritated, or compromised skin conditions. These products do not treat underlying pathology but rather provide supportive dermatological care.
Approved indications
- Dry skin and xerosis
- Eczema and atopic dermatitis (supportive care)
- General skin irritation and chafing
Common side effects
- Local skin irritation or contact dermatitis
- Allergic reaction to cream components
Key clinical trials
- Effect of MI Paste Plus™ on Streptococcus Mutans and White Spot Lesions in Fixed Orthodontics (NA)
- Auto-immunity and Pulmonary Arterial Hypertension (NA)
- Little NIRVANA for Pediatric Pain and Anxiety (NA)
- A Clinical Study Assessing the Maximum Maxillary Bite Force When Using Three Denture Adhesives Compared to Using No-Adhesive (NA)
- Comparative Evaluation of Topical Metformin and Topical Tranexamic Acid in Melasma (NA)
- Clinical Study on the Prevention and Treatment of Radiation Vaginitis With Triethanolamine Cream (PHASE4)
- Efficacy and Safety of a Botanical Total Coumarin (TC) Cream in Treating Patients With Psoriasis Vulgaris (PLANTCOAT-IIb Trial) (PHASE2)
- Effectiveness of a Bilayering Serum and Cream Containing GABA, DMAE, Cysteamine, and Bakuchiol for Skin Whitening and Anti-Aging (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- emollient cream CI brief — competitive landscape report
- emollient cream updates RSS · CI watch RSS
- Children's Hospital Medical Center, Cincinnati portfolio CI