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Emdogain (EMD) - test
Emdogain is a protein extract derived from developing tooth buds that promotes periodontal regeneration by stimulating growth factors and extracellular matrix formation.
Emdogain is a protein extract derived from developing tooth buds that promotes periodontal regeneration by stimulating growth factors and extracellular matrix formation. Used for Periodontal defects and bone loss associated with chronic periodontitis, Intrabony defects requiring periodontal regeneration.
At a glance
| Generic name | Emdogain (EMD) - test |
|---|---|
| Sponsor | Universidad Complutense de Madrid |
| Drug class | Regenerative biologic / Enamel matrix derivative |
| Target | Enamel matrix proteins (EMPs); indirect effects on growth factors and cell signaling pathways |
| Modality | Biologic |
| Therapeutic area | Dentistry / Periodontics |
| Phase | FDA-approved |
Mechanism of action
Emdogain contains enamel matrix proteins (EMPs) that mimic the natural developmental signals present during tooth formation. When applied to periodontal defects, these proteins stimulate fibroblast proliferation, cementum formation, and periodontal ligament regeneration, facilitating the restoration of lost periodontal tissues.
Approved indications
- Periodontal defects and bone loss associated with chronic periodontitis
- Intrabony defects requiring periodontal regeneration
Common side effects
- Local inflammation or swelling at application site
- Temporary discomfort or sensitivity
- Allergic reaction (rare)
Key clinical trials
- Effect of Enamel Matrix Derivative or Hyaluronic Acid on Non-Surgical Treatment of Peri-Implantitis (NA)
- Emdogain Adjunctive to Autotransplantation (PHASE4)
- Does the Non-surgical Application of Enamel Matrix Derivative Reduce the Need of Periodontal Surgical Intervention in Subjects With Severe (Stage III) Periodontitis? (PHASE3)
- Influence of Enamel Matrix Derivative (Emdogain®) on Palate Wound Healing. (NA)
- A Novel Volumetric Analysis Using CAD/CAM Scanners in Gingival Recession Treatment (NA)
- The Effect of Enamel Matrix Derivatives on Root Coverage Esthetic Score (NA)
- Semilunar Coronally Positioned Flap With or Without Enamel Matrix Derivative for the Treatment of Gingival Recessions (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Emdogain (EMD) - test CI brief — competitive landscape report
- Emdogain (EMD) - test updates RSS · CI watch RSS
- Universidad Complutense de Madrid portfolio CI