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Nestorone (elcometrine)
Nestorone (generic name: elcometrine) is a drug. It is currently in unknown development.
Nestorone is a progestin that works by binding to and activating the progesterone receptor, mimicking the effects of the hormone progesterone.
Nestorone is a small molecule progesterone receptor agonist used in birth control and the treatment of endometriosis. It is available in combination with an estrogen as a vaginal ring or implant, but not effective when taken orally.
At a glance
| Generic name | elcometrine |
|---|---|
| Therapeutic area | Other |
| Phase | unknown |
Mechanism of action
Imagine your body has a lock that progesterone fits into. Nestorone is a key that fits into the same lock, allowing it to turn on the same signals as progesterone. This can help regulate various bodily functions, such as menstrual cycles and pregnancy.
Approved indications
Common side effects
Key clinical trials
- A Study to Evaluate the Effects of Annovera™ and Tampon Co-Usage on the Pharmacokinetics of Segesterone Acetate and Ethinyl Estradiol (Phase 1)
- Clinical Evaluation of Daily Application of Nestorone® (NES) and Testosterone (T) Combination Gel for Male Contraception (Phase 2)
- An Open-Label Study of Serum Testosterone and Nestorone in Females After Secondary Exposure to Nestorone ® (NES) + Testosterone (T) Combined Gel Applied to Shoulders and Upper Arms in Males: Effect of (Phase 1)
- A Drug-Drug Interaction Study to Evaluate the Effects of Strong CYP3A Induction and Inhibition on the Pharmacokinetics of Segesterone Acetate and Ethinyl Estradiol From the Annovera™ Contraceptive Vag (Phase 1)
- A Randomized, Two Center, Double-Blind Trial to Evaluate the Pharmacokinetics and Gonadotropin Suppression of Nestorone®-Testosterone (NES/T) Combination Gel in Healthy Men (Phase 1)
- A Randomized, Open Label Clinical Trial to Evaluate if Nestorone Gel Has Gonadotropin Suppressive Activity and if Nestorone in Combination With Testosterone Will Have an Additive Effect on Gonadotropi (Phase 1)
- A Multicenter, Randomized, Double-Blind Comparator Trial of the Safety and Sperm and Gonadotropin Suppression Resulting From Combined Use of Nestorone® Gel (0, 8 or 12 mg NES) and Testosterone Gel (10 (Phase 1)
- Comparison of Vaginal Estradiol and Oral Guaifenesin Interventions in Patients Undergoing Ovulation Induction With Clomiphene Citrate (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Nestorone CI brief — competitive landscape report
- Nestorone updates RSS · CI watch RSS
- portfolio CI
Frequently asked questions about Nestorone
What is Nestorone?
How does Nestorone work?
What is the generic name of Nestorone?
What development phase is Nestorone in?
Related
- Manufacturer: — full pipeline
- Therapeutic area: All drugs in Other
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing