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Edaravone Dexborneol Sublingual Tablets
Edaravone is a free radical scavenger that reduces oxidative stress and neuroinflammation, while dexborneol enhances absorption and bioavailability through sublingual delivery.
Edaravone is a free radical scavenger that reduces oxidative stress and neuroinflammation, while dexborneol enhances absorption and bioavailability through sublingual delivery. Used for Acute ischemic stroke.
At a glance
| Generic name | Edaravone Dexborneol Sublingual Tablets |
|---|---|
| Sponsor | Peking Union Medical College Hospital |
| Drug class | Free radical scavenger with permeation enhancer |
| Target | Hydroxyl radicals and reactive oxygen species (ROS) |
| Modality | Small molecule |
| Therapeutic area | Neurology |
| Phase | Phase 3 |
Mechanism of action
Edaravone works by neutralizing hydroxyl radicals and other reactive oxygen species that accumulate during acute ischemic stroke, thereby limiting neuronal damage and apoptosis. Dexborneol, a natural monoterpene alcohol, acts as a permeation enhancer that improves the sublingual absorption of edaravone, allowing for faster systemic delivery and potentially improved clinical efficacy compared to intravenous administration.
Approved indications
- Acute ischemic stroke
Common side effects
- Headache
- Dizziness
- Nausea
- Rash or allergic reactions
Key clinical trials
- Edaravone and Dexborneol Sublingual Tablet for Treating Chemotherapy- Induced Cognitive Impairment Study (PHASE4)
- Treatment of Acute Ischemic Stroke With Edaravone Dexborneol Sublingual Tablets in Small Vessel Disease (PHASE3)
- Edaravone Dexborneol Sublingual Tablet for the PSCI in Acute Ischemic Stroke Patients (PHASE2)
- The Efficacy and Safety of Edaravone Dexborneol Sequential Therapy in the Treatment of Patients With AIS (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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