Last reviewed 2026-04-19 · How we verify

EC1456 and EC20

Endocyte · Phase 1 active Small molecule

EC1456 and EC20 is a Small molecule drug developed by Endocyte. It is currently in Phase 1 development. Also known as: Folic acid and tubulysin B hydrazide and etarfolatide.

Likelihood of approval

9.6% vs 9.6% industry baseline

If approved by FDA: likely 2033–2036

Steps remaining: Phase 2 → Phase 3 → NDA/BLA submission

Confidence: Medium

Why this estimate

Baseline phase 1 → approval rate +9.6pp
Industry-wide phase 1 drugs reach approval ~9.6% of the time (BIO/Informa 2023 industry benchmark across all therapeutic areas).

Predicted approval windows by jurisdiction (conditional on FDA approval)

Regulator	Country	Likely year	Lag vs FDA
FDA	US	2033–2036	—
EMA	EU	2034–2037	+0.7 yr
MHRA	GB	2034–2037	+0.7 yr
Health Canada	CA	2034–2038	+0.9 yr
TGA	AU	2034–2038	+1.2 yr
PMDA	JP	2034–2038	+1.5 yr
NMPA	CN	2035–2039	+2.3 yr
MFDS	KR	2034–2038	+1.4 yr
CDSCO	IN	2034–2039	+1.8 yr
ANVISA	BR	2035–2039	+2.3 yr

Hover any row for the lag rationale. Lag estimates are reduced when the drug has FDA Breakthrough or EMA PRIME designation (sponsors file globally in parallel).

Estimate based on the BIO/Informa industry phase transition rates plus per-drug modifiers for therapeutic area, sponsor type, FDA designations, mechanism, and trial design. Per-jurisdiction lags from Tufts CSDD international approval studies. Not investment, clinical or regulatory advice. Methodology: /methodology#likelihood.

At a glance

Generic name	EC1456 and EC20
Also known as	Folic acid and tubulysin B hydrazide and etarfolatide
Sponsor	Endocyte
Modality	Small molecule
Phase	Phase 1

Approved indications

No approved indications tracked.

Common side effects

No common side effects on file.

Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

EC1456 and EC20 CI brief — competitive landscape report
EC1456 and EC20 updates RSS · CI watch RSS
Endocyte portfolio CI

Frequently asked questions about EC1456 and EC20

What is EC1456 and EC20?

EC1456 and EC20 is a Small molecule drug developed by Endocyte.

Who makes EC1456 and EC20?

EC1456 and EC20 is developed by Endocyte (see full Endocyte pipeline at /company/endocyte).

Is EC1456 and EC20 also known as anything else?

EC1456 and EC20 is also known as Folic acid and tubulysin B hydrazide and etarfolatide.

What development phase is EC1456 and EC20 in?

EC1456 and EC20 is in Phase 1.

Manufacturer: Endocyte — full pipeline
Also known as: Folic acid and tubulysin B hydrazide and etarfolatide

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing