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DUOSTIM
DUOSTIM is a dual stimulation protocol combining FSH and LH for controlled ovarian hyperstimulation in assisted reproductive technology.
DUOSTIM is a dual stimulation protocol combining FSH and LH for controlled ovarian hyperstimulation in assisted reproductive technology. Used for Controlled ovarian hyperstimulation in assisted reproductive technology (ART) / in vitro fertilization (IVF), Ovulation induction in infertility treatment.
At a glance
| Generic name | DUOSTIM |
|---|---|
| Also known as | Same monthly cycle |
| Sponsor | Centre Hospitalier Intercommunal Creteil |
| Drug class | Gonadotropin combination therapy |
| Target | FSH receptor and LH receptor |
| Modality | Small molecule |
| Therapeutic area | Reproductive Medicine / Fertility |
| Phase | Phase 3 |
Mechanism of action
DUOSTIM employs simultaneous stimulation with follicle-stimulating hormone (FSH) and luteinizing hormone (LH) to promote multiple follicle development during in vitro fertilization cycles. This dual-hormone approach aims to improve oocyte yield and embryo quality compared to FSH-alone protocols, particularly in poor responders or women of advanced reproductive age.
Approved indications
- Controlled ovarian hyperstimulation in assisted reproductive technology (ART) / in vitro fertilization (IVF)
- Ovulation induction in infertility treatment
Common side effects
- Ovarian hyperstimulation syndrome (OHSS)
- Injection site reactions
- Headache
- Abdominal discomfort
Key clinical trials
- Continuous Double Ovarian Stimulation. (PHASE4)
- DUOSTIM and AI: is There a Difference Between Oocyte Performance in the Follicular and Luteal Phases?
- Protocol with Progestin-primed Ovarian Stimulation (PPOS) from the Beginning of Stimulation Versus Protocol with GnRH Antagonists for Ovarian Stimulation in Patients Undergoing DUOSTIM with Embryo Accumulation for PGT-A. (PHASE4)
- Dual Ovarian Stimulation (Duostim) and Shanghai Protocols in Poor Ovarian Responders (PHASE3)
- Double Stimulation in Women With Low Prognosis in ART (NA)
- Cumulative Live Birth Rates in Dual Ovarian Stimulation Versus Two Antagonist Stimulations in Poor Ovarian Responders (NA)
- Dual Ovarian Stimulation (DUOSTIM) for Poor Ovarian Responders (PHASE3)
- Comparison of Triggers in Double Ovarian Stimulation (DuoStim). (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- DUOSTIM CI brief — competitive landscape report
- DUOSTIM updates RSS · CI watch RSS
- Centre Hospitalier Intercommunal Creteil portfolio CI