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Dual Trigger
Dual Trigger is a protocol combining a GnRH agonist and hCG injection to induce final oocyte maturation in assisted reproductive technology.
Dual Trigger is a protocol combining a GnRH agonist and hCG injection to induce final oocyte maturation in assisted reproductive technology. Used for Final oocyte maturation triggering in IVF cycles, Reduction of ovarian hyperstimulation syndrome (OHSS) risk in high-responder patients.
At a glance
| Generic name | Dual Trigger |
|---|---|
| Also known as | Dual ovulation trigger (Choriomon and Triptorelin) |
| Sponsor | Weill Medical College of Cornell University |
| Drug class | Reproductive hormone protocol |
| Target | GnRH receptor and LH receptor |
| Modality | Small molecule |
| Therapeutic area | Reproductive Medicine / Fertility |
| Phase | FDA-approved |
Mechanism of action
The dual trigger approach uses both a GnRH agonist and human chorionic gonadotropin (hCG) administered together or in sequence to trigger the final maturation and release of eggs during in vitro fertilization (IVF) cycles. This combination has been shown to improve oocyte maturation rates and reduce ovarian hyperstimulation syndrome (OHSS) compared to hCG trigger alone, particularly in high-risk patients.
Approved indications
- Final oocyte maturation triggering in IVF cycles
- Reduction of ovarian hyperstimulation syndrome (OHSS) risk in high-responder patients
Common side effects
- Ovarian hyperstimulation syndrome (OHSS)
- Abdominal discomfort
- Headache
Key clinical trials
- IncobotulinumtoxinA for Provoked Vestibulodynia With Overactive Pelvic Floor Muscle Dysfunction (PHASE2)
- Selatogrel Outcome Study in Suspected Acute Myocardial Infarction (PHASE3)
- Topical Ketotifen 0.25% for Secondary Vestibulodynia (PHASE2)
- Effect of Two Different Fluid Treatment Regimens on Ultrasonographic Upper Airway Measurements (NA)
- Efficacy of Triamcinolone-Lidocaine Mix in Trigger Points Injection of Masseter Muscle: Double-blinded, Randomized Controlled Trial (PHASE2, PHASE3)
- Closed Loop DBS Implanted RC+S Study (NA)
- A Phase 2 Study to Evaluate the Efficacy and Safety of Pudafensine in Vulvodynia (Provoked Vestibulodynia) (PHASE2)
- Sensory Feeding and Parent Coaching for Children With ARFID (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |