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Drug: Semaglutide Administered SC
Drug: Semaglutide Administered SC is a GLP-1 receptor agonist Small molecule drug developed by BrightGene Bio-Medical Technology Co., Ltd.. It is currently in Phase 3 development for Type 2 diabetes mellitus, Chronic weight management in obese or overweight patients, Cardiovascular risk reduction in patients with type 2 diabetes.
Semaglutide is a GLP-1 receptor agonist that mimics glucagon-like peptide-1 to regulate blood glucose, suppress appetite, and promote weight loss.
Semaglutide is a GLP-1 receptor agonist that mimics glucagon-like peptide-1 to regulate blood glucose, suppress appetite, and promote weight loss. Used for Type 2 diabetes mellitus, Chronic weight management in obese or overweight patients, Cardiovascular risk reduction in patients with type 2 diabetes.
At a glance
| Generic name | Drug: Semaglutide Administered SC |
|---|---|
| Sponsor | BrightGene Bio-Medical Technology Co., Ltd. |
| Drug class | GLP-1 receptor agonist |
| Target | GLP-1R |
| Modality | Small molecule |
| Therapeutic area | Diabetes, Obesity, Cardiovascular |
| Phase | Phase 3 |
Mechanism of action
Semaglutide binds to and activates GLP-1 receptors on pancreatic beta cells, enhancing glucose-dependent insulin secretion and reducing glucagon release. It also acts on the central nervous system to reduce appetite and increase satiety, leading to decreased caloric intake and weight reduction. These combined effects improve glycemic control and cardiovascular outcomes in patients with type 2 diabetes and obesity.
Approved indications
- Type 2 diabetes mellitus
- Chronic weight management in obese or overweight patients
- Cardiovascular risk reduction in patients with type 2 diabetes
Common side effects
- Nausea
- Vomiting
- Diarrhea
- Constipation
- Abdominal pain
- Decreased appetite
- Headache
- Hypoglycemia (when combined with insulin/sulfonylureas)
Key clinical trials
- A Study to Evaluate the Safety and Efficacy of NG101 in Adult Participants Receiving a Glucagon-like Peptide-1 (GLP-1) Agonist (PHASE2)
- A Study of RAY1225 Versus Semaglutide as Add-on Therapy to Oral Antidiabetic Drugs in Participants With Type 2 Diabetes (PHASE3)
- A Study of BGM0504 in Chinese Patients With Type 2 Diabetes (PHASE2)
- A Study of BGM0504 in Participants with Type 2 Diabetes (PHASE3)
- A Research Study to Compare Two Different Forms of Once-weekly Semaglutide in Two Different Injection Pens (PHASE1)
- A Research Study to Compare Two Forms of Semaglutide in Two Different Pen-injectors in People With Overweight or Obesity (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Drug: Semaglutide Administered SC CI brief — competitive landscape report
- Drug: Semaglutide Administered SC updates RSS · CI watch RSS
- BrightGene Bio-Medical Technology Co., Ltd. portfolio CI
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Related
- Drug class: All GLP-1 receptor agonist drugs
- Target: All drugs targeting GLP-1R
- Manufacturer: BrightGene Bio-Medical Technology Co., Ltd. — full pipeline
- Therapeutic area: All drugs in Diabetes, Obesity, Cardiovascular
- Indication: Drugs for Type 2 diabetes mellitus
- Indication: Drugs for Chronic weight management in obese or overweight patients
- Indication: Drugs for Cardiovascular risk reduction in patients with type 2 diabetes
- Compare: Drug: Semaglutide Administered SC vs similar drugs
- Pricing: Drug: Semaglutide Administered SC cost, discount & access