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Drug-eluting Stent Mometasone
A drug-eluting stent that releases mometasone (a corticosteroid) locally to reduce inflammation and restenosis at the site of coronary or vascular intervention.
A drug-eluting stent that releases mometasone (a corticosteroid) locally to reduce inflammation and restenosis at the site of coronary or vascular intervention. Used for Coronary artery disease requiring percutaneous coronary intervention, Prevention of in-stent restenosis.
At a glance
| Generic name | Drug-eluting Stent Mometasone |
|---|---|
| Also known as | Mometasone |
| Sponsor | Children's Hospital Medical Center, Cincinnati |
| Drug class | Drug-eluting stent (corticosteroid-eluting) |
| Target | Glucocorticoid receptor |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | FDA-approved |
Mechanism of action
Mometasone is a potent glucocorticoid that suppresses the inflammatory response triggered by stent placement, reducing neointimal hyperplasia and the risk of in-stent restenosis. By eluting the drug directly at the intervention site over time, local anti-inflammatory effects are achieved while minimizing systemic exposure. This approach aims to improve long-term patency and reduce the need for repeat revascularization.
Approved indications
- Coronary artery disease requiring percutaneous coronary intervention
- Prevention of in-stent restenosis
Common side effects
- In-stent restenosis
- Stent thrombosis
- Myocardial infarction
- Bleeding
Key clinical trials
- Propel Drug-Eluting Sinus Stent Family Open Cohort
- Product Surveillance Registry; Ear, Nose and Throat - EXTEND Cohort
- Adjunctive Treatment for Chronic Rhinosinusitis With Nasal Polyposis (PHASE2, PHASE3)
- Use of Mometasone Eluting Stent in Choanal Atresia (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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