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Double Umbilical Cord Blood Transplant
Double umbilical cord blood transplant involves infusing two units of umbilical cord blood-derived hematopoietic stem cells to reconstitute the patient's bone marrow and immune system.
Double umbilical cord blood transplant involves infusing two units of umbilical cord blood-derived hematopoietic stem cells to reconstitute the patient's bone marrow and immune system. Used for Acute leukemia in remission, Chronic leukemia, Myelodysplastic syndrome.
At a glance
| Generic name | Double Umbilical Cord Blood Transplant |
|---|---|
| Sponsor | Medical College of Wisconsin |
| Drug class | Cell therapy / Hematopoietic stem cell transplant |
| Modality | Biologic |
| Therapeutic area | Oncology / Hematology |
| Phase | Phase 3 |
Mechanism of action
This procedure uses stem cells from two separate umbilical cord blood units to overcome the limited cell dose from a single unit, allowing successful engraftment in adult patients. The dual units provide sufficient hematopoietic progenitor cells to restore blood cell production and immune function in patients with hematologic malignancies or bone marrow disorders after myeloablative conditioning.
Approved indications
- Acute leukemia in remission
- Chronic leukemia
- Myelodysplastic syndrome
- Lymphoma
- Multiple myeloma
Common side effects
- Graft-versus-host disease (GVHD)
- Graft failure or delayed engraftment
- Infection
- Mucositis
- Organ toxicity
Key clinical trials
- Double Unit Cord Blood Transplant in Hematologic Malignancies.
- Cord Blood Transplant in Adults With Blood Cancers (PHASE2)
- Hematopoietic Stem Cell Transplantation in the Treatment of Infant Leukemia (PHASE2)
- ABBA CORD: dCBT w/ Abatacept for aGVHD Prophylaxis (PHASE2)
- Tocilizumab for the Prevention of Graft Versus Host Disease After Cord Blood Transplantation (PHASE2)
- Umbilical Cord Blood Transplant, Cyclophosphamide, Fludarabine, and Total-Body Irradiation in Treating Patients With Hematologic Disease (PHASE2)
- Treosulfan, Fludarabine Phosphate, and Total-Body Irradiation in Treating Patients With Hematological Cancer Who Are Undergoing Umbilical Cord Blood Transplant (PHASE2)
- Evaluating the Safety and Effectiveness of an Umbilical Cord Blood Stem Cell Transplant (BMT CTN 0604) (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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