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dopamine versus norepinephrine
Dopamine and norepinephrine are catecholamine medications that work by stimulating the heart and increasing blood pressure.
Dopamine and norepinephrine are catecholamine medications that work by stimulating the heart and increasing blood pressure. Used for Treatment of septic shock, Cardiogenic shock.
At a glance
| Generic name | dopamine versus norepinephrine |
|---|---|
| Sponsor | Sepsis Occurrence in Acutely Ill Patients |
| Drug class | catecholamine |
| Target | adrenergic receptors |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | Phase 3 |
Mechanism of action
Dopamine and norepinephrine are used to treat septic shock by increasing cardiac output and vascular tone. They work by binding to adrenergic receptors in the heart and blood vessels, causing an increase in heart rate and blood pressure.
Approved indications
- Treatment of septic shock
- Cardiogenic shock
Common side effects
- Hypotension
- Tachycardia
- Arrhythmias
- Myocardial ischemia
Key clinical trials
- Amino Acids in Patients With Anorexia Nervosa: Double-blind Randomized Study Versus Placebo (NA)
- Dopamine Versus Norepinephrine for the Treatment of Vasopressor Dependent Septic Shock (PHASE3)
- Dopamine Versus Norepinephrine Under General Anesthesia (PHASE3)
- The Effect of Norepinephrine Versus Dopamine in Renal Transplant Recipients on Postoperative Graft Function (PHASE2, PHASE3)
- Vasopressin Versus Catecholamines for Cerebral Perfusion Pressure Control in Brain Injured Trauma Patients (NA)
- Dopamine and Norepinephrine in Shock Patients (PHASE3)
- Microcirculation Guided Therapy Versus "Standard Treatment" of Severe Sepsis (PHASE4)
Primary sources
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| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |