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Dopamine Hydrochloride (DOPAMINE)
Dopamine Hydrochloride works by stimulating dopamine receptors in the body to increase heart rate, blood pressure, and cardiac output.
At a glance
| Generic name | DOPAMINE |
|---|---|
| Sponsor | Hospira |
| Drug class | Catecholamine |
| Target | D(1A) dopamine receptor |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | FDA-approved |
| First approval | 1974 |
Mechanism of action
Dopamine is natural catecholamine formed by the decarboxylation of 3,4-dihydroxyphenylalanine (DOPA). It is precursor to norepinephrine in noradrenergic nerves and is also neurotransmitter in certain areas of the central nervous system, especially in the nigrostriatal tract, and in few peripheral sympathetic nerves.Dopamine elicits its pharmacological action by activating dopamine D1 and D2 receptors, beta-1 receptors and alpha-1 receptors. The activation of different receptors leading to its effects are dependent on dopamine dose.
Approved indications
- Decompensated cardiac failure
- Low blood pressure
- Low cardiac output syndrome
Common side effects
- azotemia
- Gangrene of the extremities
- hypertension
- hypotension
- palpitation
- tachycardia
- vasoconstriction
- widened QRS complex
- atrial fibrillation
- bradycardia
- ectopic beats
- nausea
Drug interactions
- isocarboxazid
- linezolid
- pargyline
- phenelzine
- tranylcypromine
Key clinical trials
- Effects of Positive Psychological Group Psychotherapy and Auricular Acupressure on Withdrawal Symptoms (NA)
- Clinical Laboratory Evaluation of Chronic Autonomic Failure
- PET Scanning in Parkinson s Disease
- Diagnosis of Pheochromocytoma (PHASE1)
- Treating Parkinson's Disease Through Transplantation of Autologous Stem Cell-Derived Dopaminergic Neurons (PHASE1)
- Efficacy of Cabergoline in Inhibiting Lactation and Alleviating Breast Symptoms (PHASE2)
- Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol (PHASE3)
- Dopamine Modulation of Motivation and Motor Function in Major Depression & Inflammation (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| FDA label | Mechanism, indications, dosing, boxed warnings, drug interactions |
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |