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docetaxel, nedaplatin, and capecitabine

Sun Yat-sen University · Phase 3 active Small molecule

docetaxel, nedaplatin, and capecitabine is a Taxane, Platinum-based DNA crosslinker, Thymidylate synthase inhibitor Small molecule drug developed by Sun Yat-sen University. It is currently in Phase 3 development for Metastatic breast cancer, Metastatic non-small cell lung cancer, Metastatic gastric cancer. Also known as: TNX induction chemotherapy.

Docetaxel is a microtubule inhibitor that disrupts cell division, nedaplatin is a platinum-based DNA crosslinker, and capecitabine is a thymidylate synthase inhibitor.

Docetaxel is a microtubule inhibitor that disrupts cell division, nedaplatin is a platinum-based DNA crosslinker, and capecitabine is a thymidylate synthase inhibitor. Used for Metastatic breast cancer, Metastatic non-small cell lung cancer, Metastatic gastric cancer.

At a glance

Generic namedocetaxel, nedaplatin, and capecitabine
Also known asTNX induction chemotherapy
SponsorSun Yat-sen University
Drug classTaxane, Platinum-based DNA crosslinker, Thymidylate synthase inhibitor
TargetMicrotubules, DNA, Thymidylate synthase
ModalitySmall molecule
Therapeutic areaOncology
PhasePhase 3

Mechanism of action

Docetaxel works by binding to tubulin and preventing the formation of microtubules, which are essential for cell division. Nedaplatin forms platinum-DNA adducts, which interfere with DNA replication and transcription. Capecitabine is converted to 5-fluorouracil, which inhibits thymidylate synthase and disrupts DNA synthesis.

Approved indications

Common side effects

Key clinical trials

Primary sources

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SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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Frequently asked questions about docetaxel, nedaplatin, and capecitabine

What is docetaxel, nedaplatin, and capecitabine?

docetaxel, nedaplatin, and capecitabine is a Taxane, Platinum-based DNA crosslinker, Thymidylate synthase inhibitor drug developed by Sun Yat-sen University, indicated for Metastatic breast cancer, Metastatic non-small cell lung cancer, Metastatic gastric cancer.

How does docetaxel, nedaplatin, and capecitabine work?

Docetaxel is a microtubule inhibitor that disrupts cell division, nedaplatin is a platinum-based DNA crosslinker, and capecitabine is a thymidylate synthase inhibitor.

What is docetaxel, nedaplatin, and capecitabine used for?

docetaxel, nedaplatin, and capecitabine is indicated for Metastatic breast cancer, Metastatic non-small cell lung cancer, Metastatic gastric cancer.

Who makes docetaxel, nedaplatin, and capecitabine?

docetaxel, nedaplatin, and capecitabine is developed by Sun Yat-sen University (see full Sun Yat-sen University pipeline at /company/sun-yat-sen-university).

Is docetaxel, nedaplatin, and capecitabine also known as anything else?

docetaxel, nedaplatin, and capecitabine is also known as TNX induction chemotherapy.

What drug class is docetaxel, nedaplatin, and capecitabine in?

docetaxel, nedaplatin, and capecitabine belongs to the Taxane, Platinum-based DNA crosslinker, Thymidylate synthase inhibitor class. See all Taxane, Platinum-based DNA crosslinker, Thymidylate synthase inhibitor drugs at /class/taxane-platinum-based-dna-crosslinker-thymidylate-synthase-inhibitor.

What development phase is docetaxel, nedaplatin, and capecitabine in?

docetaxel, nedaplatin, and capecitabine is in Phase 3.

What are the side effects of docetaxel, nedaplatin, and capecitabine?

Common side effects of docetaxel, nedaplatin, and capecitabine include Neutropenia, Anemia, Thrombocytopenia, Fatigue, Nausea, Vomiting.

What does docetaxel, nedaplatin, and capecitabine target?

docetaxel, nedaplatin, and capecitabine targets Microtubules, DNA, Thymidylate synthase and is a Taxane, Platinum-based DNA crosslinker, Thymidylate synthase inhibitor.

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