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Dixon's up-and-down method
Dixon's up-and-down method is a statistical adaptive design methodology for determining optimal dose levels in clinical trials, not a pharmacological drug.
At a glance
| Generic name | Dixon's up-and-down method |
|---|---|
| Sponsor | Imam Abdulrahman Bin Faisal University |
| Modality | Small molecule |
| Phase | Phase 3 |
Mechanism of action
This is a trial design methodology rather than a therapeutic agent. It is an adaptive algorithm used in Phase I and early Phase II studies to efficiently estimate the maximum tolerated dose (MTD) or optimal biological dose by sequentially adjusting dose levels based on individual patient responses. The method is not a drug with a molecular mechanism of action.
Approved indications
Common side effects
Key clinical trials
- The Impact of Local Anesthetic Dilution on Possible Blinding for Nerve Blocks (NA)
- Propofol Dose-Finding for Colonoscope Insertion in Adult Patients (NA)
- Propofol Dose-Finding for Colonoscope Insertion in Geriatric Patients (NA)
- Effective Dose and Safety of Esketamine During Ultrasound-guided Hepatic Tumor Thermal Ablation (PHASE1, PHASE2)
- Study on the Effective Dose and Safety of Esketamine in Hysteroscopic Surgery Under Monitored Anesthesia Care (PHASE1, PHASE2)
- Optimal Concentration of Remifentanil for NIM Tube Intubation With Low-dose NMBA (NA)
- Ciprofol EC50 for Inducing Loss of Consciousness in Elderly Patients (PHASE4)
- Muscle Relaxants and Laryngeal Local Anesthetics for Laryngeal Mask Airway Insertion Decreasing Propofol in Elderly (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |