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divalproex (mood stabilizer)
Divalproex works by stabilizing mood by modulating the activity of neurotransmitters in the brain.
Divalproex works by stabilizing mood by modulating the activity of neurotransmitters in the brain. Used for Mania associated with bipolar disorder, Seizure disorders.
At a glance
| Generic name | divalproex (mood stabilizer) |
|---|---|
| Sponsor | AstraZeneca |
| Drug class | mood stabilizer |
| Modality | Small molecule |
| Therapeutic area | Neurology |
| Phase | Phase 3 |
Mechanism of action
It does this by inhibiting the reuptake of certain neurotransmitters, such as serotonin and norepinephrine, and also by reducing the release of excitatory neurotransmitters like glutamate. This leads to a decrease in the excitatory activity of neurons, which can help to stabilize mood.
Approved indications
- Mania associated with bipolar disorder
- Seizure disorders
Common side effects
- Nausea
- Dizziness
- Headache
- Somnolence
- Weight gain
- Hair loss
- Rash
- Thrombocytopenia
- Liver enzyme elevations
- Pancreatitis
Key clinical trials
- A Study to Evaluate the Efficacy and Safety of Adjunctive KarXT for the Treatment of Mania, With or Without Mixed Features, in Participants With Bipolar-I Disorder Taking Lithium, Valproate, or Lamotrigine (PHASE3)
- The Combination of Pharmacotherapy and Cognitive Behavioral Psychotherapy Under the Recovery Perspective. (PHASE1)
- Τhe Combination of Pharmacotherapy With RECOVERYTRSGR and RECOVERYTRSBDGR. (PHASE4)
- Sequential Multiple Assignment Randomized Trial for Bipolar Depression (PHASE4)
- Does The Addition Of Divalproex Sodium ER To An Atypical Antipsychotic Drug (APD) Improve Cognition And Psychopathology In Outpatients With Schizophrenia (SCH) Or Schizoaffective Disorder (SAD)? (PHASE4)
- Prediction of Clinical Response to SSRI Treatment in Bipolar Disorder Using Serotonin 1A Receptor PET Imaging (PHASE4)
- Development and Application of Precision Treatment Strategies for Common Mental Disorders (NA)
- The Role of Dopamine Metabolism in the Antidepressant Effects of Sleep Deprivation and Sertraline in Depressed Patients (PHASE1, PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |