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DIPHENHYDRAMINE CITRATE ›
Regulatory · United States
Marketing authorisations
FDA — authorised 21 December 2005
Application: NDA021394
Marketing authorisation holder: HALEON US HOLDINGS
Status: supplemented
FDA — authorised 8 July 2009
Application: ANDA090619
Marketing authorisation holder: DR REDDYS LABS LTD
Status: approved
FDA — authorised 31 May 2022
Application: ANDA216204
Marketing authorisation holder: AUROBINDO PHARMA
Status: approved
FDA — authorised 11 April 2024
Application: ANDA211404
Marketing authorisation holder: PLD ACQUISITIONS LLC
Status: approved
FDA
Safety signals — FAERS
Adverse reaction reports describe suspected side effects. A report does not mean the drug caused the event — co-medications, underlying disease and coincidence all contribute.
Window: 20 April 2025 – 20 April 2026
Total reports: 1,381
Most-reported reactions
Product Use In Unapproved Indication — 422 reports (30.56%) Drug Effective For Unapproved Indication — 385 reports (27.88%) Somnolence — 134 reports (9.7%) Drug Ineffective — 101 reports (7.31%) Off Label Use — 85 reports (6.15%) Completed Suicide — 61 reports (4.42%) Incorrect Dose Administered — 55 reports (3.98%) Product Name Confusion — 50 reports (3.62%) Underdose — 46 reports (3.33%) Fatigue — 42 reports (3.04%)
Source database →
DIPHENHYDRAMINE CITRATE in other countries
Same drug, different regulators. Each page below lists the local marketing authorisation, HTA position, pricing, and adverse-event data.
Frequently asked questions
Is DIPHENHYDRAMINE CITRATE approved in United States?
Yes. FDA authorised it on 21 December 2005; FDA authorised it on 8 July 2009; FDA authorised it on 31 May 2022.
Who is the marketing authorisation holder for DIPHENHYDRAMINE CITRATE in United States?
HALEON US HOLDINGS holds the US marketing authorisation.