Last reviewed · How we verify
Dinoprostone vaginal insert
Dinoprostone is a prostaglandin E2 analog that binds to prostaglandin receptors to stimulate uterine contractions and promote cervical ripening and labor induction.
Dinoprostone is a prostaglandin E2 analog that binds to prostaglandin receptors to stimulate uterine contractions and promote cervical ripening and labor induction. Used for Cervical ripening and labor induction in pregnant women at or near term.
At a glance
| Generic name | Dinoprostone vaginal insert |
|---|---|
| Also known as | Propess |
| Sponsor | HaEmek Medical Center, Israel |
| Drug class | Prostaglandin E2 analog |
| Target | Prostaglandin E receptors (EP1, EP3) |
| Modality | Small molecule |
| Therapeutic area | Obstetrics |
| Phase | FDA-approved |
Mechanism of action
Dinoprostone acts as a direct agonist of prostaglandin E (EP) receptors, particularly EP1 and EP3 receptors on uterine smooth muscle and cervical tissue. This binding triggers increased intracellular calcium and myometrial contractions while simultaneously softening and dilating the cervix. The vaginal insert formulation provides sustained local delivery of the prostaglandin to facilitate labor induction in pregnant women.
Approved indications
- Cervical ripening and labor induction in pregnant women at or near term
Common side effects
- Uterine hyperstimulation
- Vaginal pain or irritation
- Fever
- Nausea
- Diarrhea
- Back pain
Key clinical trials
- PGE2 Followed by Oxytocin vs Oxytocin in Term PROM (POXY-PROM) (NA)
- Oxytocin vs Prostaglandins for Labor Induction of Women With an Unfavorable Cervix After 24h of Cervical Ripening (PHASE3)
- Induction of Labor - Comparison Propess With Prostaglandin E2 Vaginal Gel and Balloon Catheter (PHASE4)
- Cervical Ripening Before Induction of Labour at Term: a Randomised Comparison of Prostin vs Propess (PHASE3)
- Cook´s Balloon Versus Dinoprostone for Labor Induction of Term Pregnancies With Fetal Growth Restriction (PHASE3)
- Gemeprost Versus Dinoprostone in First Trimester Miscarriages (PHASE2)
- Misoprostol Versus Dinoprostone in Induction of Labor (NA)
- Comparison of the Effectiveness, Safety, and Satisfaction of Different Methods for Labor Induction (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Dinoprostone vaginal insert CI brief — competitive landscape report
- Dinoprostone vaginal insert updates RSS · CI watch RSS
- HaEmek Medical Center, Israel portfolio CI