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Motofen (DIFENOXIN)
Motofen (Difenoxin) is a small molecule antidiarrheal medication that targets the mu-type opioid receptor. It was originally developed by Sebeela Ireland Ltd and remains under their ownership. FDA approved in 1978, Motofen is indicated for the treatment of diarrhea. As an off-patent medication, it is likely available in generic formulations. Key safety considerations include potential for dependence and abuse.
At a glance
| Generic name | DIFENOXIN |
|---|---|
| Sponsor | Sebela Ireland Ltd |
| Drug class | Antidiarrheal |
| Target | Mu-type opioid receptor |
| Modality | Small molecule |
| Therapeutic area | Pain |
| Phase | FDA-approved |
| First approval | 1978 |
Approved indications
- Diarrhea
Common side effects
- Nausea
- Vomiting
- Dry mouth
- Epigastric distress
- Constipation
- Dizziness and light-headedness
- Drowsiness
- Headache
- Tiredness
- Nervousness
- Insomnia
- Confusion
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| FDA label | Mechanism, indications, dosing, boxed warnings, drug interactions |