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Dexmedetomidine and Fentanyl
Dexmedetomidine and fentanyl work synergistically as a sedative-analgesic combination, with dexmedetomidine acting as an alpha-2 adrenergic agonist and fentanyl as an opioid mu-receptor agonist.
Dexmedetomidine and fentanyl work synergistically as a sedative-analgesic combination, with dexmedetomidine acting as an alpha-2 adrenergic agonist and fentanyl as an opioid mu-receptor agonist. Used for Sedation and analgesia in perioperative and critical care settings.
At a glance
| Generic name | Dexmedetomidine and Fentanyl |
|---|---|
| Also known as | Precedex |
| Sponsor | University of Jordan |
| Drug class | Sedative-analgesic combination (alpha-2 agonist + opioid) |
| Target | Alpha-2 adrenergic receptor (dexmedetomidine); mu-opioid receptor (fentanyl) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia and Perioperative Medicine |
| Phase | Phase 3 |
Mechanism of action
Dexmedetomidine selectively binds alpha-2 adrenergic receptors in the central nervous system to produce sedation, analgesia, and anxiolysis while maintaining airway reflexes. Fentanyl is a potent synthetic opioid that binds mu-opioid receptors to enhance analgesia and sedation. The combination provides complementary effects for perioperative sedation and analgesia with potentially reduced opioid requirements.
Approved indications
- Sedation and analgesia in perioperative and critical care settings
Common side effects
- Hypotension
- Bradycardia
- Respiratory depression
- Dry mouth
- Hypertension (transient)
Key clinical trials
- The Relationship Between Opioid-Free Anesthesia and Postoperative Agitation-Delirium and Quality of Recovery in Pediatric Ear, Nose, and Throat Cases Monitored With Perioperative Bispectral Index
- Cardiac Index and General Anesthesia Without Opioid. (PHASE2, PHASE3)
- Safety and Efficacy of Dexmedetomidate vs. Midazolam for Procedural Sedation During Medical Thoracoscopy (PHASE3)
- Effect of Dexmedetomidine Dosage on Postoperative Delirium in Geriatric Orthopedic Surgery (PHASE2)
- Transition From Acute to Chronic Opioid Use and Chronic Pain (EARLY_PHASE1)
- Comparison of C-Reactive Protein Levels in Traumatic Brain Injury Patients Undergoing Craniotomy With and Without Dexmedetomidine (PHASE4)
- General Anesthesia Versus Sedation By Dexmedetomidine and Ketamine With Local Infiltration for Percutaneous Transcatheter Closure of Atrial Septal Defect in Pediatric Patients (NA)
- A Comparative Study Between Combination of Propofol and Dexmedetomidine Versus Propofol Alone in Anesthesia for Rigid Bronchoscopy by Using the Patient State Index Monitor (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Dexmedetomidine and Fentanyl CI brief — competitive landscape report
- Dexmedetomidine and Fentanyl updates RSS · CI watch RSS
- University of Jordan portfolio CI