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Dexketoprofen Trometamol
Dexketoprofen trometamol is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation, pain, and fever.
Dexketoprofen trometamol is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation, pain, and fever. Used for Acute pain (postoperative, dental, musculoskeletal), Rheumatoid arthritis, Osteoarthritis.
At a glance
| Generic name | Dexketoprofen Trometamol |
|---|---|
| Also known as | Arveles 25 mg 20 tablets, Revafen(Dexketoprofen Trometamol), Enantyum, Miracox, arveles |
| Sponsor | Tokat Gaziosmanpasa University |
| Drug class | Nonsteroidal anti-inflammatory drug (NSAID) |
| Target | Cyclooxygenase-1 (COX-1) and Cyclooxygenase-2 (COX-2) |
| Modality | Small molecule |
| Therapeutic area | Pain Management, Rheumatology, Inflammation |
| Phase | FDA-approved |
Mechanism of action
As the active S-enantiomer of ketoprofen complexed with trometamol (tromethamine), dexketoprofen trometamol selectively inhibits COX-1 and COX-2 enzymes. This inhibition reduces prostaglandin production, which mediates inflammatory responses and pain signaling. The trometamol salt formulation enhances solubility and provides faster onset of action compared to standard ketoprofen.
Approved indications
- Acute pain (postoperative, dental, musculoskeletal)
- Rheumatoid arthritis
- Osteoarthritis
- Migraine
Common side effects
- Gastrointestinal upset (nausea, dyspepsia, abdominal pain)
- Headache
- Dizziness
- Gastric ulceration
- Renal impairment (with chronic use)
Key clinical trials
- Ear Pressure Points Plus Pain Meds for Faster Kidney Stone Pain Relief (NA)
- Comparing the Safety and Effectiveness of Different Doses of Morphine Administered in Spinal Anethesia for Pain Relief After Hip Replacement Surgery (PHASE4)
- Short-term Perfusion Effects: Dexketoprofen/Tramadol (NA)
- IV Magnesium in the Treatment of Acute Dysmenorrhea (NA)
- Virtual Reality for Pain and Anxiety Relief During Peripheral Angioplasty (PHASE2, PHASE3)
- Analgesic Efficacy of Transcutaneous Electrical Nerve Stimulation and Dexketoprofen in Renal Colic (PHASE4)
- Comparative Efficacy of ESPB and EOPB for Postoperative Analgesia in Laparoscopic Cholecystectomy: A Randomized Controlled Trial (External Oblique Intercostal Plan Block (EOPB) and Erector Spina Plan Block (ESPB) ) (NA)
- Pectointercostal Fascial Plane Block Chronic Pain Sternotomy (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Dexketoprofen Trometamol CI brief — competitive landscape report
- Dexketoprofen Trometamol updates RSS · CI watch RSS
- Tokat Gaziosmanpasa University portfolio CI