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Dexamethasone+Tobramycin eye drop
Dexamethasone+Tobramycin eye drop is a Corticosteroid + aminoglycoside antibiotic combination Small molecule drug developed by Azienda USL Reggio Emilia - IRCCS. It is currently FDA-approved for Bacterial ocular infections with inflammation, Post-operative ocular inflammation and infection prophylaxis, Allergic conjunctivitis with secondary bacterial infection.
Dexamethasone reduces inflammation and immune response while tobramycin kills bacteria, providing combined anti-inflammatory and antibiotic effects in the eye.
Dexamethasone reduces inflammation and immune response while tobramycin kills bacteria, providing combined anti-inflammatory and antibiotic effects in the eye. Used for Bacterial ocular infections with inflammation, Post-operative ocular inflammation and infection prophylaxis, Allergic conjunctivitis with secondary bacterial infection.
At a glance
| Generic name | Dexamethasone+Tobramycin eye drop |
|---|---|
| Sponsor | Azienda USL Reggio Emilia - IRCCS |
| Drug class | Corticosteroid + aminoglycoside antibiotic combination |
| Target | Glucocorticoid receptor (dexamethasone); bacterial 30S ribosome (tobramycin) |
| Modality | Small molecule |
| Therapeutic area | Ophthalmology |
| Phase | FDA-approved |
Mechanism of action
Dexamethasone is a corticosteroid that suppresses inflammatory cytokines and immune cell infiltration in ocular tissues. Tobramycin is an aminoglycoside antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. Together, they address both infectious and inflammatory components of ocular disease.
Approved indications
- Bacterial ocular infections with inflammation
- Post-operative ocular inflammation and infection prophylaxis
- Allergic conjunctivitis with secondary bacterial infection
Common side effects
- Ocular irritation or discomfort
- Transient blurred vision
- Allergic reaction to tobramycin
- Steroid-induced elevated intraocular pressure (with prolonged use)
Key clinical trials
- Bromfenac to Reduce Inflammation in Patients With Pseudoexfoliation Syndrome After Cataract Surgery (PHASE4)
- A Comparative Study Between Preservative With Benzalkonium Chloride vs Preservative Free Eye Drops on the Ocular Surface (PHASE4)
- VisuMax Femtosecond Laser Small Incision Lenticule Extraction for the Correction of High Myopia (NA)
- Two Trabecular Micro-bypass Stents & Postoperative Travoprost to Treat Glaucoma Subjects on Two Hypotensive Agents (PHASE4)
- Preoperative Bevacizumab Injection in Primary Pterygium in Tunisian Patients (PHASE4)
- Efficacy of Over the Counter (OTC) Povidone-Ioldine 5% for Treatment of Acute or Chronic Blepharitis (NA)
- Implantable Phakic Lens (IPCL) VS Implantable Collamer Lens (NA)
- Levo-Dexa vs. Tobra+Dexa for Prevention and Treatment of Inflammation and Prevention of Infection in Cataract Surgery (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Dexamethasone+Tobramycin eye drop CI brief — competitive landscape report
- Dexamethasone+Tobramycin eye drop updates RSS · CI watch RSS
- Azienda USL Reggio Emilia - IRCCS portfolio CI
Frequently asked questions about Dexamethasone+Tobramycin eye drop
What is Dexamethasone+Tobramycin eye drop?
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Related
- Drug class: All Corticosteroid + aminoglycoside antibiotic combination drugs
- Target: All drugs targeting Glucocorticoid receptor (dexamethasone); bacterial 30S ribosome (tobramycin)
- Manufacturer: Azienda USL Reggio Emilia - IRCCS — full pipeline
- Therapeutic area: All drugs in Ophthalmology
- Indication: Drugs for Bacterial ocular infections with inflammation
- Indication: Drugs for Post-operative ocular inflammation and infection prophylaxis
- Indication: Drugs for Allergic conjunctivitis with secondary bacterial infection
- Compare: Dexamethasone+Tobramycin eye drop vs similar drugs
- Pricing: Dexamethasone+Tobramycin eye drop cost, discount & access