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dexamethasone to injury site
Dexamethasone is a corticosteroid that suppresses the immune system and reduces inflammation by inhibiting the production of pro-inflammatory cytokines.
Dexamethasone is a corticosteroid that suppresses the immune system and reduces inflammation by inhibiting the production of pro-inflammatory cytokines. Used for Treatment of acute injuries.
At a glance
| Generic name | dexamethasone to injury site |
|---|---|
| Sponsor | Henry Ford Health System |
| Drug class | Corticosteroid |
| Modality | Small molecule |
| Therapeutic area | Immunology |
| Phase | Phase 3 |
Mechanism of action
Dexamethasone works by binding to glucocorticoid receptors, which then translocate to the nucleus and inhibit the transcription of pro-inflammatory genes. This leads to a decrease in the production of pro-inflammatory cytokines, such as IL-1, IL-6, and TNF-alpha, resulting in reduced inflammation and immune suppression.
Approved indications
- Treatment of acute injuries
Common side effects
- Adrenal insufficiency
- Cushing's syndrome
- Osteoporosis
Key clinical trials
- Platform of Randomized Adaptive Clinical Trials in Critical Illness (NA)
- Intravenous Lidocaine Plus Port-Site Ropivacaine for Recovery After Laparoscopic Surgery (PHASE3)
- Treating Rhegmatogenous Retinal Detachment by Foldable Capsular Buckle
- A Fast-track Versus Conventional Recovery Protocol in Laparoscopic Hysterctomy (NA)
- Randomized Trial of Iontophoresis Versus Injection of Corticosteroids for Lateral Epicondylitis (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- dexamethasone to injury site CI brief — competitive landscape report
- dexamethasone to injury site updates RSS · CI watch RSS
- Henry Ford Health System portfolio CI