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Dexamethasone pellet
Dexamethasone is a synthetic glucocorticoid that suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors.
Dexamethasone is a synthetic glucocorticoid that suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors. Used for Inflammatory and immune-mediated conditions requiring localized or sustained corticosteroid delivery.
At a glance
| Generic name | Dexamethasone pellet |
|---|---|
| Also known as | Ozurdex pellet |
| Sponsor | Johns Hopkins University |
| Drug class | Glucocorticoid |
| Target | Glucocorticoid receptor |
| Modality | Small molecule |
| Therapeutic area | Immunology, Inflammation |
| Phase | FDA-approved |
Mechanism of action
Dexamethasone acts as a potent corticosteroid that inhibits phospholipase A2, reducing prostaglandin and leukotriene production, and suppresses T-cell and B-cell proliferation. The pellet formulation provides sustained or localized delivery of the active ingredient. It is commonly used to reduce inflammation and immune-mediated responses in various conditions.
Approved indications
- Inflammatory and immune-mediated conditions requiring localized or sustained corticosteroid delivery
Common side effects
- Hyperglycemia
- Immunosuppression
- Hypertension
- Osteoporosis (with chronic use)
- Adrenal suppression
Key clinical trials
- The Effect of Dexamethasone in Full Pulpotomy on Postoperative Pain in Permanent Molars (NA)
- Combination OZURDEX® & EyLea® vs. OZURDEX® Monotherapy in IncompLete-Responders wIth Diabetic Macular Edema (PHASE2)
- Study of the Effectiveness of Ozurdex for the Control of Uveitis (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Dexamethasone pellet CI brief — competitive landscape report
- Dexamethasone pellet updates RSS · CI watch RSS
- Johns Hopkins University portfolio CI