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Dexamethasone for control of symptoms
Dexamethasone for control of symptoms is a Glucocorticoid (corticosteroid) Small molecule drug developed by WiSP Wissenschaftlicher Service Pharma GmbH. It is currently in Phase 3 development for Symptom control in inflammatory and autoimmune conditions, Symptom management in conditions requiring immunosuppression. Also known as: dexamethasone.
Dexamethasone is a synthetic glucocorticoid that suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors in the cytoplasm.
Dexamethasone is a synthetic glucocorticoid that suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors in the cytoplasm. Used for Symptom control in inflammatory and autoimmune conditions, Symptom management in conditions requiring immunosuppression.
At a glance
| Generic name | Dexamethasone for control of symptoms |
|---|---|
| Also known as | dexamethasone |
| Sponsor | WiSP Wissenschaftlicher Service Pharma GmbH |
| Drug class | Glucocorticoid (corticosteroid) |
| Target | Glucocorticoid receptor (GR) |
| Modality | Small molecule |
| Therapeutic area | Immunology / Inflammation |
| Phase | Phase 3 |
Mechanism of action
Dexamethasone enters cells and binds to intracellular glucocorticoid receptors, which then translocate to the nucleus and modulate gene transcription. This leads to decreased production of pro-inflammatory cytokines, reduced immune cell activation and proliferation, and suppression of inflammatory mediators. These effects result in broad anti-inflammatory and immunosuppressive actions that control symptoms across multiple conditions.
Approved indications
- Symptom control in inflammatory and autoimmune conditions
- Symptom management in conditions requiring immunosuppression
Common side effects
- Hyperglycemia
- Hypertension
- Insomnia
- Mood changes
- Immunosuppression / increased infection risk
- Osteoporosis (with chronic use)
- Adrenal suppression
Key clinical trials
- Treatment of Inflammatory Myelitis and Optic Neuritis With Early vs Rescue Plasma Exchange (TIMELY-PLEX) (PHASE3)
- Dexamethasone for Ureteral STent Symptoms (DUSTS) (PHASE1, PHASE2)
- Interleukin-6 Guided Treatment With Dexamethasone or Tocilizumab in Patients Hospitalized With Acute Respiratory Symptoms - a Feasibility Study (PHASE2)
- Electroacupuncture for Chemotherapy-Induced GI Symptom Clusters in Breast Cancer (PHASE3)
- Decitabine-primed Tandem CD19/CD20 CAR T Cells Treatment in r/r B-NHL (PHASE1, PHASE2)
- Accelerated Checkpoint Therapy for Any Steroid Dependent Patient With Brain Metastases (PHASE2)
- Triple Therapy of Dexamethasone, Palonosetron, and Fosaprepitant As PONV Prevention (NA)
- Post-operative Course of Dexamethasone to Reduce Tonsillectomy Morbidity (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Dexamethasone for control of symptoms CI brief — competitive landscape report
- Dexamethasone for control of symptoms updates RSS · CI watch RSS
- WiSP Wissenschaftlicher Service Pharma GmbH portfolio CI
Frequently asked questions about Dexamethasone for control of symptoms
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Related
- Drug class: All Glucocorticoid (corticosteroid) drugs
- Target: All drugs targeting Glucocorticoid receptor (GR)
- Manufacturer: WiSP Wissenschaftlicher Service Pharma GmbH — full pipeline
- Therapeutic area: All drugs in Immunology / Inflammation
- Indication: Drugs for Symptom control in inflammatory and autoimmune conditions
- Indication: Drugs for Symptom management in conditions requiring immunosuppression
- Also known as: dexamethasone
- Compare: Dexamethasone for control of symptoms vs similar drugs
- Pricing: Dexamethasone for control of symptoms cost, discount & access