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Dexamethasone, Cytarabine, Etoposide, Pegylated-asparaginase
Dexamethasone, Cytarabine, Etoposide, Pegylated-asparaginase is a Combination chemotherapy regimen Small molecule drug developed by Children's Cancer Group, China. It is currently in Phase 3 development for Acute lymphoblastic leukemia (ALL) in pediatric patients, Acute myeloid leukemia (AML) in pediatric patients. Also known as: HR 3'.
This combination regimen uses a corticosteroid, cytotoxic chemotherapy agents, and an amino acid-depleting enzyme to induce apoptosis and inhibit protein synthesis in leukemic cells.
This combination regimen uses a corticosteroid, cytotoxic chemotherapy agents, and an amino acid-depleting enzyme to induce apoptosis and inhibit protein synthesis in leukemic cells. Used for Acute lymphoblastic leukemia (ALL) in pediatric patients, Acute myeloid leukemia (AML) in pediatric patients.
At a glance
| Generic name | Dexamethasone, Cytarabine, Etoposide, Pegylated-asparaginase |
|---|---|
| Also known as | HR 3' |
| Sponsor | Children's Cancer Group, China |
| Drug class | Combination chemotherapy regimen |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 3 |
Mechanism of action
Dexamethasone is a corticosteroid that promotes apoptosis in lymphoid cells. Cytarabine and etoposide are chemotherapy agents that inhibit DNA synthesis and topoisomerase II respectively, causing cell death. Pegylated-asparaginase depletes asparagine, an amino acid essential for leukemic cell protein synthesis, particularly affecting cells dependent on exogenous asparagine supply.
Approved indications
- Acute lymphoblastic leukemia (ALL) in pediatric patients
- Acute myeloid leukemia (AML) in pediatric patients
Common side effects
- Myelosuppression
- Infection
- Nausea and vomiting
- Mucositis
- Hyperglycemia
- Pancreatitis
- Hepatotoxicity
Key clinical trials
- Capizzi Escalating Methotrexate Versus High Dose Methotrexate in Children With Newly Diagnosed T-cell Lymphoblastic Lymphoma (T-LBL) (PHASE3)
- LBL-2016 for Children or Adolescents in China (PHASE3)
- Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (PHASE3)
- 05-001: Treatment of Acute Lymphoblastic Leukemia in Children (PHASE3)
- Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Children and Adolescents (PHASE3)
- Optimization of Therapy in Adult Patients With Newly Diagnosed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma by Individualised, Targeted and Intensified Treatment (PHASE3)
- Total Therapy for Infants With Acute Lymphoblastic Leukemia (ALL) I (PHASE1, PHASE2)
- Total Therapy XVII for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia and Lymphoma (PHASE2, PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Dexamethasone, Cytarabine, Etoposide, Pegylated-asparaginase CI brief — competitive landscape report
- Dexamethasone, Cytarabine, Etoposide, Pegylated-asparaginase updates RSS · CI watch RSS
- Children's Cancer Group, China portfolio CI
Frequently asked questions about Dexamethasone, Cytarabine, Etoposide, Pegylated-asparaginase
What is Dexamethasone, Cytarabine, Etoposide, Pegylated-asparaginase?
How does Dexamethasone, Cytarabine, Etoposide, Pegylated-asparaginase work?
What is Dexamethasone, Cytarabine, Etoposide, Pegylated-asparaginase used for?
Who makes Dexamethasone, Cytarabine, Etoposide, Pegylated-asparaginase?
Is Dexamethasone, Cytarabine, Etoposide, Pegylated-asparaginase also known as anything else?
What drug class is Dexamethasone, Cytarabine, Etoposide, Pegylated-asparaginase in?
What development phase is Dexamethasone, Cytarabine, Etoposide, Pegylated-asparaginase in?
What are the side effects of Dexamethasone, Cytarabine, Etoposide, Pegylated-asparaginase?
Related
- Drug class: All Combination chemotherapy regimen drugs
- Manufacturer: Children's Cancer Group, China — full pipeline
- Therapeutic area: All drugs in Oncology
- Indication: Drugs for Acute lymphoblastic leukemia (ALL) in pediatric patients
- Indication: Drugs for Acute myeloid leukemia (AML) in pediatric patients
- Also known as: HR 3'
- Compare: Dexamethasone, Cytarabine, Etoposide, Pegylated-asparaginase vs similar drugs
- Pricing: Dexamethasone, Cytarabine, Etoposide, Pegylated-asparaginase cost, discount & access