Last reviewed · How we verify
Dex infusion
Dexamethasone infusion delivers a corticosteroid systemically to reduce inflammation and suppress immune responses.
Dexamethasone infusion delivers a corticosteroid systemically to reduce inflammation and suppress immune responses. Used for Acute inflammation and immune suppression (specific indications not detailed in available information).
At a glance
| Generic name | Dex infusion |
|---|---|
| Sponsor | Seoul National University Hospital |
| Drug class | Corticosteroid (glucocorticoid) |
| Target | Glucocorticoid receptor (GR) |
| Modality | Small molecule |
| Therapeutic area | Immunology / Inflammation |
| Phase | FDA-approved |
Mechanism of action
Dexamethasone is a synthetic glucocorticoid that binds to glucocorticoid receptors in the cytoplasm, translocates to the nucleus, and modulates gene transcription to suppress pro-inflammatory cytokine production, reduce immune cell activation, and decrease vascular permeability. The intravenous infusion formulation allows rapid systemic delivery for acute inflammatory or immunological conditions.
Approved indications
- Acute inflammation and immune suppression (specific indications not detailed in available information)
Common side effects
- Hyperglycemia
- Insomnia
- Mood changes
- Immunosuppression / increased infection risk
- Hypertension
Key clinical trials
- Effect of Lidocaine Infusion Versus Dexmedemidine Infusion on the Neurocognitive Function of Elderly Patients Undergoing Endoscopic Retrograde Cholangiopancreatography(ERCP): a Randomized, Controlled Trial. (NA)
- A Study to Determine Dose, Safety, Tolerability and Efficacy of CC-220 Monotherapy, and in Combination With Other Treatments in Subjects With Multiple Myeloma (PHASE1, PHASE2)
- The Effect of Dexmedetomidine Infusion Alone Versus the Combination of Dexmedetomidine and Melatonin on Reduction of Post-operative Delirium (POD) After Open Brain Surgeries (PHASE4)
- Effect of Dexmedetomidine Dosage on Postoperative Delirium in Geriatric Orthopedic Surgery (PHASE2)
- Perioperative Multimodal Analgesia Protocol for Supratentorial Craniotomy (NA)
- DEXmedetomidine for Postoperative Analgesia and Delirium Prevention After NEUROsurgery (DEX-NEURO Trial) (NA)
- Intrathecal Morphine for Recovery and Outcomes After VATS (NA)
- Prophylactic Dexamethasone Before Infliximab in Moderate-to-Severe IBD
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Dex infusion CI brief — competitive landscape report
- Dex infusion updates RSS · CI watch RSS
- Seoul National University Hospital portfolio CI