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Detrol LA
Detrol LA is a muscarinic receptor antagonist that blocks acetylcholine signaling in the bladder to reduce involuntary muscle contractions and urinary urgency.
Detrol LA is a muscarinic receptor antagonist that blocks acetylcholine signaling in the bladder to reduce involuntary muscle contractions and urinary urgency. Used for Overactive bladder with symptoms of urge incontinence, urgency, and frequency.
At a glance
| Generic name | Detrol LA |
|---|---|
| Sponsor | Pfizer's Upjohn has merged with Mylan to form Viatris Inc. |
| Drug class | Muscarinic receptor antagonist |
| Target | M2 and M3 muscarinic acetylcholine receptors |
| Modality | Small molecule |
| Therapeutic area | Urology |
| Phase | FDA-approved |
Mechanism of action
Detrol LA (tolterodine tartrate extended-release) selectively antagonizes M2 and M3 muscarinic receptors in the detrusor muscle of the bladder. By blocking acetylcholine-mediated contractions, it decreases the frequency and urgency of urination and increases bladder capacity, providing symptomatic relief of overactive bladder.
Approved indications
- Overactive bladder with symptoms of urge incontinence, urgency, and frequency
Common side effects
- Dry mouth
- Headache
- Constipation
- Dizziness
- Blurred vision
Key clinical trials
- A Multidisciplinary, Multimodal Bundled Care Approach to Chronic Pelvic Pain (PHASE3)
- Efficacy and Tolerability of DITROPAN XL (Oxybutynin Chloride) Versus DETROL LA (Tolterodine Tartrate) in Treatment of Overactive Bladder (PHASE3)
- A Study to Evaluate Safety and Efficacy of YM178 in Patients With Overactive Bladder (PHASE3)
- A Prospective, Observational, Multicenter Study of Patients Following Initiation of a New Course of Treatment for Overactive Bladder (OAB)
- Inflammation in Women With Urgency Urinary Incontinence Treated With Anticholinergics (PHASE4)
- Tolterodine Drug Use Investigation.(Post Marketing Commitment Plan)
- Effect Of Detrol LA With Behavioral Intervention In Overactive Bladder Subjects Dissatisfied With Recent OAB Medication. (PHASE4)
- Effects Of Detrol LA On Memory And Cognition In Elderly Population (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |