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Desflurane with remifentanil
Desflurane is a volatile anesthetic that depresses the central nervous system, while remifentanil is an opioid agonist that provides analgesia and enhances anesthesia.
Desflurane is a volatile anesthetic that depresses the central nervous system, while remifentanil is an opioid agonist that provides analgesia and enhances anesthesia. Used for General anesthesia for surgical procedures.
At a glance
| Generic name | Desflurane with remifentanil |
|---|---|
| Also known as | desflurane with remifetanil group |
| Sponsor | Chung-Ang University Hosptial, Chung-Ang University College of Medicine |
| Drug class | Volatile anesthetic with opioid analgesic |
| Target | GABA receptors (desflurane); mu-opioid receptors (remifentanil) |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
Desflurane works by enhancing inhibitory GABAergic neurotransmission and inhibiting excitatory glutamatergic signaling in the brain, producing unconsciousness and amnesia. Remifentanil binds to mu-opioid receptors in the central nervous system to provide rapid-onset analgesia and potentiate the anesthetic effect. Together, this combination provides balanced general anesthesia with rapid emergence due to remifentanil's ultra-short half-life.
Approved indications
- General anesthesia for surgical procedures
Common side effects
- Hypotension
- Bradycardia
- Respiratory depression
- Postoperative nausea and vomiting
- Emergence agitation
Key clinical trials
- Low-Flow Sevoflurane and Desflurane Anesthesia in Laparoscopic Cholecystectomy (NA)
- Opioid-Free vs Opioid-Based Anesthesia in Bariatric Surgery (NA)
- The Effect of the Anticholinergic Burden Following Elective Coronary Artery Surgery (PHASE4)
- Continuous Versus 1-min Oscillometric Arterial BP Monitoring (NA)
- Inhalational Agents Versus Dexmedetomidine for Maintenance of General Anesthesia (NA)
- Psychosocial Factors and Postoperative Pain in Aesthetic Breast Surgery
- Effects of an Opioid Free/Sparing Care Pathway for Patients Undergoing Obesity Surgery (NA)
- Oxidative Stress Effects of TIVA, CIVA, and Balanced Anesthesia in VATS (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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