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dehydrated alcohol
dehydrated alcohol is a Small molecule drug developed by American Medical Systems. It is currently FDA-approved for Hypertrophic Obstructive Cardiomyopathy Treatment. Also known as: Ethanol.
Dehydrated alcohol causes myocardial infarction by injecting it into a target septal vessel, leading to thinning of the hypertrophied septum.
Dehydrated alcohol, marketed by American Medical Systems, is a unique treatment for Hypertrophic Obstructive Cardiomyopathy, leveraging a well-established mechanism to reduce septal thickness. Its key strength lies in its direct and effective method of causing myocardial infarction in the target septal vessel, providing a precise therapeutic approach. The primary risk is the upcoming key composition patent expiry in 2028, which could lead to increased competition.
At a glance
| Generic name | dehydrated alcohol |
|---|---|
| Also known as | Ethanol |
| Sponsor | American Medical Systems |
| Modality | Small molecule |
| Phase | FDA-approved |
Mechanism of action
When dehydrated alcohol is injected through an intra-arterial catheter into a specific blood vessel in the heart, it acts as a tissue toxin. This toxin damages the heart muscle, causing a localized heart attack (myocardial infarction) in the targeted area, which results in the thinning of the thickened part of the heart wall (hypertrophied septum).
Approved indications
- Hypertrophic Obstructive Cardiomyopathy Treatment
Common side effects
- Nausea
- Vomiting
- Renal toxicity
- Pneumonitis
- Pulmonary toxicity
- Myelosuppression
- Anorexia
- Diarrhea
- Headaches
- Alopecia
- Erythema
- Hyperpigmentation
Serious adverse events
- Interstitial lung disease
- Renal failure
- Acute leukemia
- Veno-occlusive disease
- Encephalopathy
- Seizures
- Opportunistic infection
- Bone marrow dysplasias
- Skin necrosis
- Progressive azotemia
Key clinical trials
- Characterization Imaging Instruments in Alcoholics and Non-Alcoholics
- A Study to Evaluate Mazdutide Compared With Placebo in Participants With Alcohol Use Disorder (PHASE2)
- Effect of Alcohol Sclerotherapy on Pelvic Pain and Quality of Life in Women With Ovarian Endometriosis (NA)
- Tirzepatide in MetALD (PHASE2)
- NIAAA Natural History Protocol
- Hepatic Lipid Metabolism-Alcohol Use Disorder
- Assessment of Non-Invasive Testing in Major Liver-Related Outcomes
- Virtual Reality (VR) NATURE - Alcohol Use Disorder (AUD) (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- dehydrated alcohol CI brief — competitive landscape report
- dehydrated alcohol updates RSS · CI watch RSS
- American Medical Systems portfolio CI
Frequently asked questions about dehydrated alcohol
What is dehydrated alcohol?
How does dehydrated alcohol work?
What is dehydrated alcohol used for?
Who makes dehydrated alcohol?
Is dehydrated alcohol also known as anything else?
What development phase is dehydrated alcohol in?
What are the side effects of dehydrated alcohol?
Related
- Manufacturer: American Medical Systems — full pipeline
- Indication: Drugs for Hypertrophic Obstructive Cardiomyopathy Treatment
- Also known as: Ethanol
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing