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Deep neuromuscular block
Deep neuromuscular block is a Small molecule drug developed by University of Medicine and Pharmacy at Ho Chi Minh City. It is currently FDA-approved for Facilitation of endotracheal intubation during general anesthesia, Maintenance of neuromuscular blockade during surgical procedures. Also known as: Esmeron and Bridion, high dose rocuronium, Deep neuromuscular block with rocumeron, deep relaxation.
Deep neuromuscular block refers to a state of profound neuromuscular blockade achieved through administration of neuromuscular blocking agents that inhibit acetylcholine at the neuromuscular junction.
Deep neuromuscular block refers to a state of profound neuromuscular blockade achieved through administration of neuromuscular blocking agents that inhibit acetylcholine at the neuromuscular junction. Used for Facilitation of endotracheal intubation during general anesthesia, Maintenance of neuromuscular blockade during surgical procedures.
At a glance
| Generic name | Deep neuromuscular block |
|---|---|
| Also known as | Esmeron and Bridion, high dose rocuronium, Deep neuromuscular block with rocumeron, deep relaxation |
| Sponsor | University of Medicine and Pharmacy at Ho Chi Minh City |
| Target | Nicotinic acetylcholine receptor at the neuromuscular junction |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
Deep neuromuscular blockade is induced by neuromuscular blocking drugs (typically rocuronium or other non-depolarizing agents) that competitively antagonize acetylcholine receptors at the motor endplate, preventing muscle contraction. This is a pharmacological state rather than a discrete drug product, used clinically during anesthesia and surgery to facilitate intubation and optimize surgical conditions. The depth is monitored using train-of-four stimulation and other neuromuscular monitoring techniques.
Approved indications
- Facilitation of endotracheal intubation during general anesthesia
- Maintenance of neuromuscular blockade during surgical procedures
Common side effects
- Residual neuromuscular blockade
- Histamine release (agent-dependent)
- Prolonged paralysis
Key clinical trials
- Association of Sarcopenia With Rocuronium Use in Liver Transplant Recipients (NA)
- Deep Versus Moderate Neuromuscular Blocking (NA)
- Muscle and Fat Mass in Preoperative Computed Tomography and a Neuromuscular Blocking Agent Dose
- Effect of Neuromuscular Block Depth on Driving Pressure and Postoperative Respiratory Events in Abdominal Surgeries (NA)
- Dexmedetomidine for Improving Emergence Quality in Thyroid Surgery (PHASE4)
- The Effect of Deep Versus Moderate Muscle Relaxants in Men During and After Robotic Surgery for Prostate Cancer (PHASE2)
- Brainstem Dysfunction in COVID-19 Critically Ill Patients: a Prospective Observational Study (NA)
- Comparison of the Performances of the cTOFR and the mTOFR During Reversal of Deep Neuromuscular Blockade With Sugammadex
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Deep neuromuscular block CI brief — competitive landscape report
- Deep neuromuscular block updates RSS · CI watch RSS
- University of Medicine and Pharmacy at Ho Chi Minh City portfolio CI
Frequently asked questions about Deep neuromuscular block
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Related
- Target: All drugs targeting Nicotinic acetylcholine receptor at the neuromuscular junction
- Manufacturer: University of Medicine and Pharmacy at Ho Chi Minh City — full pipeline
- Therapeutic area: All drugs in Anesthesiology
- Indication: Drugs for Facilitation of endotracheal intubation during general anesthesia
- Indication: Drugs for Maintenance of neuromuscular blockade during surgical procedures
- Also known as: Esmeron and Bridion, high dose rocuronium, Deep neuromuscular block with rocumeron, deep relaxation
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing