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Darunavir, Ritonavir, Truvada
Darunavir, Ritonavir, Truvada is a Antiretroviral combination therapy (protease inhibitor + reverse transcriptase inhibitors) Small molecule drug developed by Imperial College London. It is currently FDA-approved for HIV-1 infection in treatment-naïve and treatment-experienced patients, HIV-1 prevention (pre-exposure prophylaxis with Truvada component). Also known as: Prezista, Norvir, Truvada.
This combination inhibits HIV protease and reverse transcriptase to suppress viral replication.
This combination inhibits HIV protease and reverse transcriptase to suppress viral replication. Used for HIV-1 infection in treatment-naïve and treatment-experienced patients, HIV-1 prevention (pre-exposure prophylaxis with Truvada component).
At a glance
| Generic name | Darunavir, Ritonavir, Truvada |
|---|---|
| Also known as | Prezista, Norvir, Truvada |
| Sponsor | Imperial College London |
| Drug class | Antiretroviral combination therapy (protease inhibitor + reverse transcriptase inhibitors) |
| Target | HIV protease, HIV reverse transcriptase, CYP3A4 |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease / Virology |
| Phase | FDA-approved |
Mechanism of action
Darunavir is a protease inhibitor that blocks HIV protease, preventing the maturation of viral particles. Ritonavir is a pharmacokinetic booster that inhibits cytochrome P450 metabolism, increasing darunavir levels. Truvada (tenofovir/emtricitabine) are nucleoside reverse transcriptase inhibitors that block viral reverse transcriptase. Together, they suppress HIV replication through multiple mechanisms.
Approved indications
- HIV-1 infection in treatment-naïve and treatment-experienced patients
- HIV-1 prevention (pre-exposure prophylaxis with Truvada component)
Common side effects
- Diarrhea
- Nausea
- Headache
- Rash
- Elevated lipids
- Renal impairment (Truvada component)
Key clinical trials
- Study of Cobicistat-Boosted Atazanavir (ATV/co), Cobicistat-Boosted Darunavir (DRV/co) and Emtricitabine/Tenofovir Alafenamide (F/TAF) in Children With HIV (PHASE2, PHASE3)
- A Study to Provide Continued Access to Study Drug to Children and Adolescents Who Have Completed Clinical Studies Involving Gilead HIV Treatments (PHASE4)
- Trial to Evaluate the Interest of a Reductive Anti Retroviral Strategy Using Dual Therapy Inspite of Triple Therapy (PHASE3)
- Cost-effectiveness of Different Antiretroviral Treatment in Patients HIV Naive (PHASE4)
- Safety and Efficacy of Doravirine (MK-1439) in Participants With Human Immunodeficiency Virus 1 (HIV-1) (MK-1439-018) (PHASE3)
- Dual Therapy With Boosted Darunavir + Dolutegravir (PHASE3)
- Research In Viral Eradication of HIV Reservoirs (PHASE2)
- Study to Evaluate Efficacy and Safety of Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (D/C/F/TAF) Regimen Versus Boosted Protease Inhibitor (bPI) Along With Emtricitabine/Tenofovir Disoproxil Fumarate (FTC/TDF) Regimen in Virologically-Suppressed, HIV-1 Infected Participants (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Darunavir, Ritonavir, Truvada CI brief — competitive landscape report
- Darunavir, Ritonavir, Truvada updates RSS · CI watch RSS
- Imperial College London portfolio CI
Frequently asked questions about Darunavir, Ritonavir, Truvada
What is Darunavir, Ritonavir, Truvada?
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Who makes Darunavir, Ritonavir, Truvada?
Is Darunavir, Ritonavir, Truvada also known as anything else?
What drug class is Darunavir, Ritonavir, Truvada in?
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What does Darunavir, Ritonavir, Truvada target?
Related
- Drug class: All Antiretroviral combination therapy (protease inhibitor + reverse transcriptase inhibitors) drugs
- Target: All drugs targeting HIV protease, HIV reverse transcriptase, CYP3A4
- Manufacturer: Imperial College London — full pipeline
- Therapeutic area: All drugs in Infectious Disease / Virology
- Indication: Drugs for HIV-1 infection in treatment-naïve and treatment-experienced patients
- Indication: Drugs for HIV-1 prevention (pre-exposure prophylaxis with Truvada component)
- Also known as: Prezista, Norvir, Truvada
- Compare: Darunavir, Ritonavir, Truvada vs similar drugs
- Pricing: Darunavir, Ritonavir, Truvada cost, discount & access