Last reviewed · How we verify
Daratumumab with dexamethasone
Daratumumab with dexamethasone is a Monoclonal antibody Small molecule drug developed by Hellenic Society of Hematology. It is currently in Phase 2 development for Multiple myeloma. Also known as: DaraD, Darzalex, Dara, Dex.
Daratumumab is a monoclonal antibody that targets CD38, a protein found on the surface of multiple myeloma cells.
Daratumumab is a monoclonal antibody that targets CD38, a protein found on the surface of multiple myeloma cells. Used for Multiple myeloma.
At a glance
| Generic name | Daratumumab with dexamethasone |
|---|---|
| Also known as | DaraD, Darzalex, Dara, Dex |
| Sponsor | Hellenic Society of Hematology |
| Drug class | Monoclonal antibody |
| Target | CD38 |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 2 |
Mechanism of action
By binding to CD38, daratumumab triggers the destruction of these cancer cells. This mechanism is thought to be responsible for the therapeutic effects of daratumumab in multiple myeloma. The addition of dexamethasone, a corticosteroid, is believed to enhance the efficacy of daratumumab by modulating the immune response and reducing inflammation.
Approved indications
- Multiple myeloma
Common side effects
- Fatigue
- Nausea
- Diarrhea
- Thrombocytopenia
- Anemia
Key clinical trials
- A Study Comparing Anitocabtagene Autoleucel to Standard of Care Therapy in Participants With Relapsed/ Refractory Multiple Myeloma (PHASE3)
- Fixed Duration vs Continuous Daratumumab in Transplant Ineligible Older Adults With Newly Diagnosed Multiple Myeloma (PHASE3)
- Comparing the Combination of Selinexor-Daratumumab-Velcade-Dexamethasone (Dara-SVD) With the Usual Treatment (Dara-RVD) for High-Risk Newly Diagnosed Multiple Myeloma (PHASE2)
- Testing the Investigational Medication Combination of Daratumumab and Teclistamab Compared to the Usual Treatment (Daratumumab, Pomalidomide, Dexamethasone or Daratumumab, Carfilzomib, Dexamethasone) for Patients With High-risk Multiple Myeloma Refractory or in First Relapse (PHASE2)
- A Study to Learn About the Study Medicine Elranatamab Alone and With Daratumumab in People With Multiple Myeloma Who Have Received Other Treatments (PHASE3)
- A Study to Learn How Safe and How Well Linvoseltamab Works Compared to Standard Treatment in Adult Patients With Multiple Myeloma Who Are Not Eligible for Transplant (PHASE3)
- A Study of GR1803 Injection Versus Daratumumab, Pomalidomide, and Dexamethasone (DPd) in Participants With Relapsed or Refractory Multiple Myeloma (PHASE3)
- Subcutaneous Daratumumab, Once Weekly Carfilzomib, and Dexamethasone (DKd) in Patients With High-Risk Smoldering Multiple Myeloma (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Daratumumab with dexamethasone CI brief — competitive landscape report
- Daratumumab with dexamethasone updates RSS · CI watch RSS
- Hellenic Society of Hematology portfolio CI
Frequently asked questions about Daratumumab with dexamethasone
What is Daratumumab with dexamethasone?
How does Daratumumab with dexamethasone work?
What is Daratumumab with dexamethasone used for?
Who makes Daratumumab with dexamethasone?
Is Daratumumab with dexamethasone also known as anything else?
What drug class is Daratumumab with dexamethasone in?
What development phase is Daratumumab with dexamethasone in?
What are the side effects of Daratumumab with dexamethasone?
What does Daratumumab with dexamethasone target?
Related
- Drug class: All Monoclonal antibody drugs
- Target: All drugs targeting CD38
- Manufacturer: Hellenic Society of Hematology — full pipeline
- Therapeutic area: All drugs in Oncology
- Indication: Drugs for Multiple myeloma
- Also known as: DaraD, Darzalex, Dara, Dex
- Compare: Daratumumab with dexamethasone vs similar drugs
- Pricing: Daratumumab with dexamethasone cost, discount & access