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Dapsone 5.0% Gel (Allergan)

Seegpharm S.A. · Phase 3 active Small molecule

Dapsone is a sulfone antibiotic that inhibits bacterial dihydropteroate synthase and has anti-inflammatory properties through suppression of neutrophil function and reactive oxygen species production.

Dapsone is a sulfone antibiotic that inhibits bacterial dihydropteroate synthase and has anti-inflammatory properties through suppression of neutrophil function and reactive oxygen species production. Used for Acne vulgaris (topical gel formulation).

At a glance

Generic nameDapsone 5.0% Gel (Allergan)
Also known asActive Comparator
SponsorSeegpharm S.A.
Drug classSulfone antibiotic with anti-inflammatory properties
TargetDihydropteroate synthase (bacterial); neutrophil function and ROS production (host)
ModalitySmall molecule
Therapeutic areaDermatology
PhasePhase 3

Mechanism of action

Dapsone works through dual mechanisms: as an antimicrobial agent targeting bacterial folate synthesis, and as an anti-inflammatory agent that suppresses neutrophil-mediated inflammation. In topical gel formulation for acne, it primarily leverages its anti-inflammatory and antimicrobial properties to reduce acne lesions and associated inflammation.

Approved indications

Common side effects

Key clinical trials

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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