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D3 vitamin
Vitamin D3 (cholecalciferol) is converted in the body to its active form, calcitriol, which regulates calcium and phosphate homeostasis and modulates immune function.
Vitamin D3 (cholecalciferol) is converted in the body to its active form, calcitriol, which regulates calcium and phosphate homeostasis and modulates immune function. Used for Vitamin D deficiency, Hypocalcemia, Osteoporosis prevention and treatment.
At a glance
| Generic name | D3 vitamin |
|---|---|
| Also known as | D3 Vitamin ®, supplied by D3 Pharmacy Ltd, D3 |
| Sponsor | Medical University of Lodz |
| Drug class | Vitamin D supplement / Secosteroid |
| Target | Vitamin D receptor (VDR) |
| Modality | Small molecule |
| Therapeutic area | Endocrinology / Bone metabolism / Immunology |
| Phase | FDA-approved |
Mechanism of action
Vitamin D3 is a fat-soluble vitamin that undergoes hydroxylation in the liver and kidneys to form the active hormone calcitriol (1,25-dihydroxyvitamin D3). This active metabolite binds to the vitamin D receptor (VDR) in target tissues, promoting intestinal calcium and phosphate absorption, regulating bone mineralization, and modulating immune cell differentiation and function. It plays a critical role in maintaining serum calcium levels and skeletal health.
Approved indications
- Vitamin D deficiency
- Hypocalcemia
- Osteoporosis prevention and treatment
- Hypoparathyroidism
Common side effects
- Hypercalcemia
- Hypercalciuria
- Nausea
- Vomiting
- Constipation
Key clinical trials
- Effect of Tirzepatide and Bimagrumab on Body Composition, Insulin Sensitivity, and Bone in Adults With Obesity (PHASE2)
- Acute Vitamin D Supplementation on Testosterone in Females (NA)
- Impact of Vitamin D Supplementation on the Rate of Pathologic Complete Response in Vitamin D Deficient Patients (PHASE2)
- Effect of the Consumption of Cookies Enriched With Plant Proteins and of a Vitamin D Supplement on the Progression of Sarcopenia in the Elderly (NA)
- Effects of Cofrogliptin on Beta-Cell Function in LADA Patients (NA)
- Effect of Vitamin D and Folic Acid on Mild Cognitive Impairment (NA)
- Frequency of Fibromyalgia Syndrome in Elderly Patients Aged 80 and Above and Its Relationship With Geriatric Parameters
- Vitamin D Supplementation During Pregnancy for Prevention of Asthma in Childhood (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- D3 vitamin CI brief — competitive landscape report
- D3 vitamin updates RSS · CI watch RSS
- Medical University of Lodz portfolio CI