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Cyclosporins
Cyclosporins is a Small molecule drug developed by Shengyun Lin. It is currently FDA-approved. Also known as: cyclosporine A, Neoral, Sandimmune, Gengraf.
Cyclosporins are a group of macrolides isolated from fungi and used as immunosuppressant drugs, primarily for preventing the body's immune response after transplant surgery. They work by modulating the activity of cyclophilin A, a protein involved in the immune response, through their action as a peptidyl-prolyl cis-trans isomerase A modulator.
At a glance
| Generic name | Cyclosporins |
|---|---|
| Also known as | cyclosporine A, Neoral, Sandimmune, Gengraf, CSA |
| Sponsor | Shengyun Lin |
| Modality | Small molecule |
| Therapeutic area | Other |
| Phase | FDA-approved |
Approved indications
Common side effects
Key clinical trials
- Radiation- and Alkylator-free Bone Marrow Transplantation Regimen for Patients With Dyskeratosis Congenita (PHASE2)
- Campath/Fludarabine/Melphalan Transplant Conditioning for Non-Malignant Diseases (PHASE1, PHASE2)
- Rituximab Plus Cyclosporine in Idiopathic Membranous Nephropathy (PHASE2)
- Letermovir Prophylaxis in Children With EBV-Positive T/NK-Cell Lymphoproliferative Disease and Refractory/Relapsed EBV-Associated Hemophagocytic Lymphohistiocytosis (NA)
- A Study to Evaluate Axatilimab Versus Best Available Therapy in Participants With Chronic Graft Versus Host Disease After at Least 2 Prior Lines of Systemic Therapy (PHASE3)
- A Study to Evaluate Axatilimab Versus Best Available Therapy in Pediatric Participants With Chronic Graft-Versus-Host Disease After at Least 2 Prior Lines of Systemic Therapy (AGAVE-256) (PHASE2)
- Study on the Efficacy and Safety of the TmBU Conditioning Regimen in High-risk or Relapsed/Refractory Acute Leukemia (PHASE2)
- Effect of Anti-Psoriatic Biologics on Risk of Anogenital Warts (CONDYPSO)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Cyclosporins CI brief — competitive landscape report
- Cyclosporins updates RSS · CI watch RSS
- Shengyun Lin portfolio CI
Frequently asked questions about Cyclosporins
What is Cyclosporins?
Who makes Cyclosporins?
Is Cyclosporins also known as anything else?
What development phase is Cyclosporins in?
Related
- Manufacturer: Shengyun Lin — full pipeline
- Therapeutic area: All drugs in Other
- Also known as: cyclosporine A, Neoral, Sandimmune, Gengraf, CSA
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing