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Cyclophosphamide, Vindelsine, Cytarabine, Doxorubincin, Prednisone

Children's Cancer Group, China · Phase 2 active Small molecule

Cyclophosphamide, Vindelsine, Cytarabine, Doxorubincin, Prednisone is a Alkylating agent, Topoisomerase inhibitor, Nucleoside analog, Anthracycline antibiotic, Corticosteroid Small molecule drug developed by Children's Cancer Group, China. It is currently in Phase 2 development for Acute lymphoblastic leukemia, Acute myeloid leukemia, Non-Hodgkin's lymphoma, Hodgkin's lymphoma, Multiple sclerosis. Also known as: Protocol AA.

Cyclophosphamide is an alkylating agent that interferes with DNA replication, Vindelsine is a topoisomerase inhibitor that disrupts DNA replication, Cytarabine is a nucleoside analog that inhibits DNA synthesis, Doxorubicin is an anthracycline antibiotic that intercalates DNA, Prednisone is a corticosteroid that suppresses inflammation and immune response.

Cyclophosphamide is an alkylating agent that interferes with DNA replication, Vindelsine is a topoisomerase inhibitor that disrupts DNA replication, Cytarabine is a nucleoside analog that inhibits DNA synthesis, Doxorubicin is an anthracycline antibiotic that intercalates DNA, Prednisone is a corticosteroid that suppresses inflammation and immune response. Used for Acute lymphoblastic leukemia, Acute myeloid leukemia, Non-Hodgkin's lymphoma, Hodgkin's lymphoma, Multiple sclerosis.

At a glance

Generic nameCyclophosphamide, Vindelsine, Cytarabine, Doxorubincin, Prednisone
Also known asProtocol AA
SponsorChildren's Cancer Group, China
Drug classAlkylating agent, Topoisomerase inhibitor, Nucleoside analog, Anthracycline antibiotic, Corticosteroid
TargetDNA, Topoisomerase II, DNA polymerase, DNA, Glucocorticoid receptor
ModalitySmall molecule
Therapeutic areaOncology
PhasePhase 2

Mechanism of action

These drugs work by targeting different stages of the cell cycle and DNA replication. Cyclophosphamide and Doxorubicin cause DNA damage, while Cytarabine and Vindelsine interfere with DNA synthesis. Prednisone suppresses the immune system and reduces inflammation.

Approved indications

Common side effects

Key clinical trials

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

Competitive intelligence

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Frequently asked questions about Cyclophosphamide, Vindelsine, Cytarabine, Doxorubincin, Prednisone

What is Cyclophosphamide, Vindelsine, Cytarabine, Doxorubincin, Prednisone?

Cyclophosphamide, Vindelsine, Cytarabine, Doxorubincin, Prednisone is a Alkylating agent, Topoisomerase inhibitor, Nucleoside analog, Anthracycline antibiotic, Corticosteroid drug developed by Children's Cancer Group, China, indicated for Acute lymphoblastic leukemia, Acute myeloid leukemia, Non-Hodgkin's lymphoma, Hodgkin's lymphoma, Multiple sclerosis.

How does Cyclophosphamide, Vindelsine, Cytarabine, Doxorubincin, Prednisone work?

Cyclophosphamide is an alkylating agent that interferes with DNA replication, Vindelsine is a topoisomerase inhibitor that disrupts DNA replication, Cytarabine is a nucleoside analog that inhibits DNA synthesis, Doxorubicin is an anthracycline antibiotic that intercalates DNA, Prednisone is a corticosteroid that suppresses inflammation and immune response.

What is Cyclophosphamide, Vindelsine, Cytarabine, Doxorubincin, Prednisone used for?

Cyclophosphamide, Vindelsine, Cytarabine, Doxorubincin, Prednisone is indicated for Acute lymphoblastic leukemia, Acute myeloid leukemia, Non-Hodgkin's lymphoma, Hodgkin's lymphoma, Multiple sclerosis.

Who makes Cyclophosphamide, Vindelsine, Cytarabine, Doxorubincin, Prednisone?

Cyclophosphamide, Vindelsine, Cytarabine, Doxorubincin, Prednisone is developed by Children's Cancer Group, China (see full Children's Cancer Group, China pipeline at /company/children-s-cancer-group-china).

Is Cyclophosphamide, Vindelsine, Cytarabine, Doxorubincin, Prednisone also known as anything else?

Cyclophosphamide, Vindelsine, Cytarabine, Doxorubincin, Prednisone is also known as Protocol AA.

What drug class is Cyclophosphamide, Vindelsine, Cytarabine, Doxorubincin, Prednisone in?

Cyclophosphamide, Vindelsine, Cytarabine, Doxorubincin, Prednisone belongs to the Alkylating agent, Topoisomerase inhibitor, Nucleoside analog, Anthracycline antibiotic, Corticosteroid class. See all Alkylating agent, Topoisomerase inhibitor, Nucleoside analog, Anthracycline antibiotic, Corticosteroid drugs at /class/alkylating-agent-topoisomerase-inhibitor-nucleoside-analog-anthracycline-antibiotic-corticosteroid.

What development phase is Cyclophosphamide, Vindelsine, Cytarabine, Doxorubincin, Prednisone in?

Cyclophosphamide, Vindelsine, Cytarabine, Doxorubincin, Prednisone is in Phase 2.

What are the side effects of Cyclophosphamide, Vindelsine, Cytarabine, Doxorubincin, Prednisone?

Common side effects of Cyclophosphamide, Vindelsine, Cytarabine, Doxorubincin, Prednisone include Myelosuppression, Nausea and vomiting, Hair loss, Infection, Steroid-induced psychosis.

What does Cyclophosphamide, Vindelsine, Cytarabine, Doxorubincin, Prednisone target?

Cyclophosphamide, Vindelsine, Cytarabine, Doxorubincin, Prednisone targets DNA, Topoisomerase II, DNA polymerase, DNA, Glucocorticoid receptor and is a Alkylating agent, Topoisomerase inhibitor, Nucleoside analog, Anthracycline antibiotic, Corticosteroid.

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