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cyclophosphamide, vincristine, prednisone, dacarbazine
cyclophosphamide, vincristine, prednisone, dacarbazine is a Alkylating agent, Vinca alkaloid, Corticosteroid Small molecule drug developed by University of Giessen. It is currently in Phase 3 development for Hodgkin's lymphoma, Non-Hodgkin's lymphoma, Multiple myeloma. Also known as: CYC, VCR, PRED, DTIC.
Cyclophosphamide is an alkylating agent that interferes with DNA replication, vincristine is a vinca alkaloid that inhibits microtubule formation, prednisone is a corticosteroid that suppresses inflammation, and dacarbazine is an alkylating agent that interferes with DNA replication.
Cyclophosphamide is an alkylating agent that interferes with DNA replication, vincristine is a vinca alkaloid that inhibits microtubule formation, prednisone is a corticosteroid that suppresses inflammation, and dacarbazine is an alkylating agent that interferes with DNA replication. Used for Hodgkin's lymphoma, Non-Hodgkin's lymphoma, Multiple myeloma.
At a glance
| Generic name | cyclophosphamide, vincristine, prednisone, dacarbazine |
|---|---|
| Also known as | CYC, VCR, PRED, DTIC |
| Sponsor | University of Giessen |
| Drug class | Alkylating agent, Vinca alkaloid, Corticosteroid |
| Target | Microtubules, DNA |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 3 |
Mechanism of action
Cyclophosphamide and dacarbazine work by adding alkyl groups to DNA, which interferes with DNA replication and causes cell death. Vincristine works by binding to tubulin and preventing microtubule formation, which is necessary for cell division. Prednisone suppresses inflammation by inhibiting the production of inflammatory cytokines.
Approved indications
- Hodgkin's lymphoma
- Non-Hodgkin's lymphoma
- Multiple myeloma
Common side effects
- Myelosuppression
- Nausea and vomiting
- Diarrhea
- Fatigue
- Infection
Key clinical trials
- A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab (PHASE3)
- Pediatric Classical Hodgkin Lymphoma Consortium Study: cHOD17 (PHASE2)
- Safety and Efficacy of Pembrolizumab (MK-3475) in Children and Young Adults With Classical Hodgkin Lymphoma (MK-3475-667/KEYNOTE-667) (PHASE2)
- Adcetris (Brentuximab Vedotin), Combination Chemotherapy, and Radiation Therapy in Treating Younger Patients With Stage IIB, IIIB and IV Hodgkin Lymphoma (PHASE2)
- PET-Adapted First-Line Therapy With Nivolumab for Advanced Hodgkin Lymphoma (PHASE2)
- Comparison of Two Combination Chemotherapy Regimens in Treating Patients With Stage III or Stage IV Hodgkin's Lymphoma (PHASE3)
- Study of Safety and Efficacy of Pembrolizumab and Chemotherapy in Participants With Newly Diagnosed Classical Hodgkin Lymphoma (cHL) (MK-3475-C11/KEYNOTE-C11) (PHASE2)
- HD21 for Advanced Stages (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- cyclophosphamide, vincristine, prednisone, dacarbazine CI brief — competitive landscape report
- cyclophosphamide, vincristine, prednisone, dacarbazine updates RSS · CI watch RSS
- University of Giessen portfolio CI
Frequently asked questions about cyclophosphamide, vincristine, prednisone, dacarbazine
What is cyclophosphamide, vincristine, prednisone, dacarbazine?
How does cyclophosphamide, vincristine, prednisone, dacarbazine work?
What is cyclophosphamide, vincristine, prednisone, dacarbazine used for?
Who makes cyclophosphamide, vincristine, prednisone, dacarbazine?
Is cyclophosphamide, vincristine, prednisone, dacarbazine also known as anything else?
What drug class is cyclophosphamide, vincristine, prednisone, dacarbazine in?
What development phase is cyclophosphamide, vincristine, prednisone, dacarbazine in?
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Related
- Drug class: All Alkylating agent, Vinca alkaloid, Corticosteroid drugs
- Target: All drugs targeting Microtubules, DNA
- Manufacturer: University of Giessen — full pipeline
- Therapeutic area: All drugs in Oncology
- Indication: Drugs for Hodgkin's lymphoma
- Indication: Drugs for Non-Hodgkin's lymphoma
- Indication: Drugs for Multiple myeloma
- Also known as: CYC, VCR, PRED, DTIC
- Compare: cyclophosphamide, vincristine, prednisone, dacarbazine vs similar drugs
- Pricing: cyclophosphamide, vincristine, prednisone, dacarbazine cost, discount & access