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Cultured autologous keratinocytes

Association of Dutch Burn Centres · Phase 3 active Biologic

Cultured autologous keratinocytes is a Cell therapy; autologous cellular product Biologic drug developed by Association of Dutch Burn Centres. It is currently in Phase 3 development for Severe thermal burns requiring skin grafting. Also known as: Cultured keratinocytes.

Cultured autologous keratinocytes are patient-derived skin cells grown in vitro and applied topically to promote wound healing and skin regeneration in severe burn injuries.

Cultured autologous keratinocytes are patient-derived skin cells grown in vitro and applied topically to promote wound healing and skin regeneration in severe burn injuries. Used for Severe thermal burns requiring skin grafting.

At a glance

Generic nameCultured autologous keratinocytes
Also known asCultured keratinocytes
SponsorAssociation of Dutch Burn Centres
Drug classCell therapy; autologous cellular product
ModalityBiologic
Therapeutic areaDermatology; Wound Care; Burn Treatment
PhasePhase 3

Mechanism of action

This therapy involves harvesting a small sample of the patient's own keratinocytes (skin cells), expanding them in culture to create a large sheet of living skin tissue, and then grafting this autologous cellular product onto burn wounds. The cultured keratinocytes restore the epidermal barrier, promote wound closure, reduce infection risk, and facilitate natural healing by providing viable skin cells that integrate with the patient's existing tissue.

Approved indications

Common side effects

Key clinical trials

Primary sources

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SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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Frequently asked questions about Cultured autologous keratinocytes

What is Cultured autologous keratinocytes?

Cultured autologous keratinocytes is a Cell therapy; autologous cellular product drug developed by Association of Dutch Burn Centres, indicated for Severe thermal burns requiring skin grafting.

How does Cultured autologous keratinocytes work?

Cultured autologous keratinocytes are patient-derived skin cells grown in vitro and applied topically to promote wound healing and skin regeneration in severe burn injuries.

What is Cultured autologous keratinocytes used for?

Cultured autologous keratinocytes is indicated for Severe thermal burns requiring skin grafting.

Who makes Cultured autologous keratinocytes?

Cultured autologous keratinocytes is developed by Association of Dutch Burn Centres (see full Association of Dutch Burn Centres pipeline at /company/association-of-dutch-burn-centres).

Is Cultured autologous keratinocytes also known as anything else?

Cultured autologous keratinocytes is also known as Cultured keratinocytes.

What drug class is Cultured autologous keratinocytes in?

Cultured autologous keratinocytes belongs to the Cell therapy; autologous cellular product class. See all Cell therapy; autologous cellular product drugs at /class/cell-therapy-autologous-cellular-product.

What development phase is Cultured autologous keratinocytes in?

Cultured autologous keratinocytes is in Phase 3.

What are the side effects of Cultured autologous keratinocytes?

Common side effects of Cultured autologous keratinocytes include Graft failure or poor integration, Infection at graft site, Contracture formation, Hypertrophic scarring.

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