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CSII followed by Lina
CSII (continuous subcutaneous insulin infusion) followed by liraglutide (Lina) provides basal-bolus insulin delivery combined with GLP-1 receptor agonism to improve glycemic control in diabetes.
CSII (continuous subcutaneous insulin infusion) followed by liraglutide (Lina) provides basal-bolus insulin delivery combined with GLP-1 receptor agonism to improve glycemic control in diabetes. Used for Type 2 diabetes mellitus requiring intensive glycemic control.
At a glance
| Generic name | CSII followed by Lina |
|---|---|
| Also known as | CSII+Lina |
| Sponsor | Sun Yat-sen University |
| Drug class | Combination therapy: insulin (basal-bolus) + GLP-1 receptor agonist |
| Target | Insulin receptor (CSII component); GLP-1 receptor (liraglutide component) |
| Modality | Small molecule |
| Therapeutic area | Endocrinology / Diabetes |
| Phase | FDA-approved |
Mechanism of action
This combination therapy uses an insulin pump (CSII) to deliver continuous background insulin with meal-time boluses, while liraglutide enhances insulin secretion, slows gastric emptying, and promotes satiety through GLP-1 receptor activation. The sequential or concurrent use aims to optimize blood glucose management while potentially reducing insulin requirements and supporting weight loss.
Approved indications
- Type 2 diabetes mellitus requiring intensive glycemic control
Common side effects
- Hypoglycemia
- Nausea
- Injection site reactions
- Gastrointestinal disturbances
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- CSII followed by Lina CI brief — competitive landscape report
- CSII followed by Lina updates RSS · CI watch RSS
- Sun Yat-sen University portfolio CI