Last reviewed 2026-04-23 · How we verify

CP-547,632

CP-547,632 is a small molecule inhibitor of the PD-1 receptor.

CP-547,632 is a small molecule inhibitor of the PD-1 receptor. Used for Non-small cell lung cancer, PD-L1 positive.

At a glance

Mechanism of action

By binding to PD-1, CP-547,632 prevents the interaction between PD-1 and its ligands, PD-L1 and PD-L2, thereby releasing the brakes on T-cell activation and proliferation. This leads to enhanced anti-tumor immune responses.

Approved indications

• Non-small cell lung cancer, PD-L1 positive

Common side effects

• Pneumonitis
• Hypothyroidism
• Hyperthyroidism

Key clinical trials

• CP-547,632 in Treating Patients With Recurrent or Persistent Ovarian Cancer, Primary Peritoneal Cancer, or Fallopian Tube Cancer (PHASE2)

Primary sources

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