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COT
COT is a corticosteroid that functions as an anti-inflammatory agent.
COT is a corticosteroid that functions as an anti-inflammatory agent. Used for Asthma, Chronic obstructive pulmonary disease (COPD).
At a glance
| Generic name | COT |
|---|---|
| Also known as | COT with olfactory stimulants |
| Sponsor | Evon Medics LLC |
| Drug class | corticosteroid |
| Target | glucocorticoid receptor |
| Modality | Small molecule |
| Therapeutic area | Respiratory |
| Phase | FDA-approved |
Mechanism of action
Corticosteroids like COT exert their effects by binding to glucocorticoid receptors, which then translocate to the nucleus and alter gene expression to reduce inflammation. This results in decreased production of pro-inflammatory cytokines and increased production of anti-inflammatory cytokines.
Approved indications
- Asthma
- Chronic obstructive pulmonary disease (COPD)
Common side effects
- Oral thrush
- Hypersensitivity reactions
- Gastrointestinal upset
Key clinical trials
- VINTAGE (Ventricular Intramyocardial Navigation for Tachycardia Ablation Guided by Electrograms) Using Commercial Off-The-Shelf (COTS) Catheters (NA)
- High Flow Nasal Cannula Rates in Pediatric Asthma (NA)
- Augmenting Urinary Reflex Activity Study 4 (Including eXtended Indications) (NA)
- Standardizing Swallow Pressure Measurements (NA)
- The Role of Environmental Temperatures in Respiratory Control (NA)
- Postoperative High-flow Nasal Oxygenation After High-risk Surgery in the Frail Adult (NA)
- Comparison of Outcomes of Early Kangaroo Mother Care and Standard Method Care in Healthy Low Birth Weight Preterm Neonates at a Tertiary Care Hospital (NA)
- Telemedicine Anesthesia Consultation, Pilot Study in Obstetrics.
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- COT CI brief — competitive landscape report
- COT updates RSS · CI watch RSS
- Evon Medics LLC portfolio CI