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Corticotropin-Releasing Hormone
Corticotropin-Releasing Hormone stimulates the release of adrenocorticotropic hormone (ACTH) from the pituitary gland, which in turn increases cortisol production.
Corticotropin-Releasing Hormone stimulates the release of adrenocorticotropic hormone (ACTH) from the pituitary gland, which in turn increases cortisol production. Used for Treatment of major depressive disorder.
At a glance
| Generic name | Corticotropin-Releasing Hormone |
|---|---|
| Also known as | corticorelin |
| Sponsor | Centre for Addiction and Mental Health |
| Target | CRHR1, CRHR2 |
| Modality | Small molecule |
| Therapeutic area | Psychiatry |
| Phase | Phase 2 |
Mechanism of action
When CRH binds to its receptors in the anterior pituitary gland, it triggers a cascade that leads to the synthesis and secretion of ACTH. This hormone then acts on the adrenal cortex to produce and release cortisol, which plays a role in stress response and metabolism.
Approved indications
- Treatment of major depressive disorder
Common side effects
- Headache
- Nausea
Key clinical trials
- CRF2 Agonist for the Treatment of Worsening Heart Failure (PHASE2)
- Chromosome 18 Clinical Research Center
- The Effect of Sulfasalazine on CRH Levels in Pregnant Women (PHASE2)
- Hormonal Mechanisms of Sleep Restriction - Axis Study in Older Men and Postmenopausal Women (EARLY_PHASE1)
- Hormonal Mechanisms of Sleep Restriction - Axis Study (PHASE1)
- Reducing Pregnancy Risks: The Mastery Lifestyle Intervention (NA)
- Imaging CRF X NOP Interactions in CUD (EARLY_PHASE1)
- Cardiorespiratory Fitness Training in Patients with Incomplete Spinal Cord Injury (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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