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Corticosteroid Injections
Corticosteroid injections suppress local inflammation and immune responses by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production.
Corticosteroid injections suppress local inflammation and immune responses by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production. Used for Intra-articular inflammation and pain in hand and upper extremity joints, Tenosynovitis and tendon sheath inflammation, Carpal tunnel syndrome (corticosteroid injection).
At a glance
| Generic name | Corticosteroid Injections |
|---|---|
| Also known as | Methylprednisolone, Depo-medrol |
| Sponsor | Christine M. Kleinert Institute for Hand and Microsurgery |
| Drug class | Corticosteroid |
| Target | Glucocorticoid receptor |
| Modality | Small molecule |
| Therapeutic area | Rheumatology, Orthopedics, Hand Surgery |
| Phase | FDA-approved |
Mechanism of action
Corticosteroids work by penetrating cell membranes and binding to intracellular glucocorticoid receptors, which then translocate to the nucleus and modulate gene expression. This leads to decreased production of inflammatory mediators (cytokines, chemokines, adhesion molecules) and reduced recruitment and activation of immune cells. When injected locally, they provide high local concentrations while minimizing systemic exposure.
Approved indications
- Intra-articular inflammation and pain in hand and upper extremity joints
- Tenosynovitis and tendon sheath inflammation
- Carpal tunnel syndrome (corticosteroid injection)
- Trigger finger
Common side effects
- Local pain or discomfort at injection site
- Temporary increase in pain (post-injection flare)
- Local tissue atrophy
- Infection at injection site
- Transient hyperglycemia
Key clinical trials
- pAF for the Treatment of Osteoarthritis (PHASE1, PHASE2)
- OMT for Adhesive Capsulitis (PHASE4)
- A Norwegian Trial Comparing Treatment Strategies for Carpal Tunnel Syndrome (PHASE4)
- Tocilizumab in Lung Transplantation (PHASE2)
- Capsular Distension Versus Corticosteroid Injection in Adhesive Capsulitis (NA)
- Evolution of Post-Stroke Shoulder Pain With a Capsular Pattern With Physiotherapy Alone Versus Coupled With Mild Arthrographic Distension With Cortisone (PHASE4)
- A Study of Lebrikizumab in Adult Participants With Perennial Allergic Rhinitis (PREPARED-1) (PHASE3)
- A Study of Lebrikizumab (LY3650150) in Participants With Chronic Rhinosinusitis and Nasal Polyps Treated With Intranasal Corticosteroids (CONTRAST-NP) (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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