Last reviewed · How we verify
Coordinated bolus
Coordinated bolus is a clinical protocol for synchronized insulin delivery designed to optimize postprandial glucose control.
Coordinated bolus is a clinical protocol for synchronized insulin delivery designed to optimize postprandial glucose control. Used for Type 1 diabetes mellitus (insulin-dependent glucose management).
At a glance
| Generic name | Coordinated bolus |
|---|---|
| Sponsor | University Hospital, Toulouse |
| Modality | Small molecule |
| Therapeutic area | Endocrinology/Diabetes |
| Phase | FDA-approved |
Mechanism of action
This appears to be a therapeutic approach or clinical protocol rather than a discrete pharmaceutical agent. It involves coordinated timing of insulin bolus administration, likely in the context of insulin pump therapy or diabetes management, to better match meal intake and glucose dynamics. The mechanism focuses on improving glycemic control through optimized insulin dosing coordination.
Approved indications
- Type 1 diabetes mellitus (insulin-dependent glucose management)
Common side effects
- Hypoglycemia
- Hyperglycemia
Key clinical trials
- Biofeedback as an Adjunctive Treatment for Post-stroke Dysphagia (NA)
- Clinical Trial of an Anti-cancer Drug, CA-4948 (Emavusertib), in Combination With Chemotherapy Treatment (FOLFOX Plus Bevacizumab) in Metastatic Colorectal Cancer (PHASE1)
- PReoperative Chemoradiation (Paclitaxel-carboplatin or FOLFOX) for Resectable Esophageal and Junctional Cancer (PHASE2)
- A Phase II Study of AMT-676 Combination Therapies in Advanced Colorectal Cancer (PHASE2)
- Substudy 06C: A Study of Investigational Agents With Pembrolizumab (MK-3475) and Chemotherapy in Participants With First-Line Locally Advanced Unresectable/Metastatic Gastroesophageal Adenocarcinoma (MK-3475-06C/KEYMAKER-U06) (PHASE1, PHASE2)
- A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer (PHASE3)
- A Study of Zolbetuximab Together With Pembrolizumab and Chemotherapy in Adults With Gastric Cancer (PHASE3)
- Study of Pembrolizumab (MK-3475) Versus Chemotherapy in Chinese Participants With Stage IV Colorectal Cancer (MK-3475-C66) (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Coordinated bolus CI brief — competitive landscape report
- Coordinated bolus updates RSS · CI watch RSS
- University Hospital, Toulouse portfolio CI