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Continuous rocuronium infusion
Rocuronium is a non-depolarizing neuromuscular blocking agent that competitively antagonizes acetylcholine at the nicotinic acetylcholine receptor on the motor endplate, causing muscle paralysis.
Rocuronium is a non-depolarizing neuromuscular blocking agent that competitively antagonizes acetylcholine at the nicotinic acetylcholine receptor on the motor endplate, causing muscle paralysis. Used for Neuromuscular blockade during general anesthesia for surgical procedures, Neuromuscular blockade in mechanically ventilated intensive care unit patients.
At a glance
| Generic name | Continuous rocuronium infusion |
|---|---|
| Sponsor | University Hospital, Antwerp |
| Drug class | Non-depolarizing neuromuscular blocking agent |
| Target | Nicotinic acetylcholine receptor (motor endplate) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia / Critical Care |
| Phase | Phase 3 |
Mechanism of action
Rocuronium binds reversibly to nicotinic acetylcholine receptors at the neuromuscular junction, preventing acetylcholine from binding and triggering muscle contraction. Continuous infusion maintains sustained neuromuscular blockade during prolonged surgical procedures or in mechanically ventilated intensive care patients. The drug is metabolized hepatically and renally, with effects reversible by sugammadex (a selective relaxant binding agent) or spontaneous recovery over time.
Approved indications
- Neuromuscular blockade during general anesthesia for surgical procedures
- Neuromuscular blockade in mechanically ventilated intensive care unit patients
Common side effects
- Prolonged neuromuscular blockade
- Histamine release (flushing, hypotension, tachycardia)
- Anaphylaxis
- Residual neuromuscular blockade
Key clinical trials
- Effect of Neuromuscular Block Depth on Driving Pressure and Postoperative Respiratory Events in Abdominal Surgeries (NA)
- Comparison of Anesthetic Techniques for Early Recovery After Ankle Arthroscopy (NA)
- Opioid-Free vs Opioid-Based Anesthesia in Bariatric Surgery (NA)
- Magnesium Sulfate Versus Other Anesthesia Drugs to Reduce Agitation After Adenotonsillectomy in Pediatric Patients (NA)
- Continuous Versus 1-min Oscillometric Arterial BP Monitoring (NA)
- TetraGraph in Rocuronium Infusions (NA)
- Inhalational Agents Versus Dexmedetomidine for Maintenance of General Anesthesia (NA)
- Intraoperative Multimodal Monitoring as a Means in Reducing the Duration of Mechanical Ventilation in High-Risk Patients Undergoing Major Abdominal Procedures - A Pilot Study (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Continuous rocuronium infusion CI brief — competitive landscape report
- Continuous rocuronium infusion updates RSS · CI watch RSS
- University Hospital, Antwerp portfolio CI