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Continuos ceftazidime/avibactam infusion
Continuos ceftazidime/avibactam infusion is a Beta-lactam/beta-lactamase inhibitor combination Small molecule drug developed by Ivan Šitum, MD. It is currently FDA-approved for Complicated urinary tract infections (cUTI) including pyelonephritis, Complicated intra-abdominal infections (cIAI), Hospital-acquired bacterial pneumonia (HABP) and ventilator-associated bacterial pneumonia (VABP).
Ceftazidime/avibactam is a beta-lactam antibiotic combined with a beta-lactamase inhibitor that kills bacteria by inhibiting cell wall synthesis while protecting the antibiotic from enzymatic degradation.
Ceftazidime/avibactam is a beta-lactam antibiotic combined with a beta-lactamase inhibitor that kills bacteria by inhibiting cell wall synthesis while protecting the antibiotic from enzymatic degradation. Used for Complicated urinary tract infections (cUTI) including pyelonephritis, Complicated intra-abdominal infections (cIAI), Hospital-acquired bacterial pneumonia (HABP) and ventilator-associated bacterial pneumonia (VABP).
At a glance
| Generic name | Continuos ceftazidime/avibactam infusion |
|---|---|
| Sponsor | Ivan Šitum, MD |
| Drug class | Beta-lactam/beta-lactamase inhibitor combination |
| Target | Penicillin-binding proteins (PBPs); serine beta-lactamases |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease |
| Phase | FDA-approved |
Mechanism of action
Ceftazidime is a third-generation cephalosporin that binds to penicillin-binding proteins and disrupts bacterial cell wall synthesis. Avibactam is a non-beta-lactam beta-lactamase inhibitor that protects ceftazidime from degradation by serine beta-lactamases, including extended-spectrum beta-lactamases (ESBLs), AmpC beta-lactamases, and some carbapenemases. Continuous infusion delivery maintains sustained bactericidal concentrations.
Approved indications
- Complicated urinary tract infections (cUTI) including pyelonephritis
- Complicated intra-abdominal infections (cIAI)
- Hospital-acquired bacterial pneumonia (HABP) and ventilator-associated bacterial pneumonia (VABP)
- Carbapenem-resistant Enterobacteriaceae (CRE) infections
Common side effects
- Diarrhea
- Nausea
- Headache
- Phlebitis at infusion site
- Hypersensitivity reactions
Key clinical trials
- CONTinuous Infusion Versus Intermittent Dosing of ceftaZidime/AVIbactam in Critically Ill Patients (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Continuos ceftazidime/avibactam infusion CI brief — competitive landscape report
- Continuos ceftazidime/avibactam infusion updates RSS · CI watch RSS
- Ivan Šitum, MD portfolio CI
Frequently asked questions about Continuos ceftazidime/avibactam infusion
What is Continuos ceftazidime/avibactam infusion?
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Related
- Drug class: All Beta-lactam/beta-lactamase inhibitor combination drugs
- Target: All drugs targeting Penicillin-binding proteins (PBPs); serine beta-lactamases
- Manufacturer: Ivan Šitum, MD — full pipeline
- Therapeutic area: All drugs in Infectious Disease
- Indication: Drugs for Complicated urinary tract infections (cUTI) including pyelonephritis
- Indication: Drugs for Complicated intra-abdominal infections (cIAI)
- Indication: Drugs for Hospital-acquired bacterial pneumonia (HABP) and ventilator-associated bacterial pneumonia (VABP)